THY1 and ITGAV

Number of citations of the paper that reports this interaction (PMID 15897908)
15

Data Source:
HPRD (in vitro, in vivo)

		THY1	ITGAV
Gene Name		Thy-1 cell surface antigen	integrin, alpha V
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Apical Plasma Membrane Dendrite Growth Cone Anchored Component Of External Side Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Rho GTPase Activator Activity Integrin Binding Protein Binding Protein Kinase Binding GPI Anchor Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Single Organismal Cell-cell Adhesion Negative Regulation Of Cell Migration Positive Regulation Of Rho GTPase Activity Positive Regulation Of GTPase Activity Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ATXN1L ATXN7 FYN ITGAM ITGAV ITGB3 LCK	28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1
Entrez ID		7070	3685
HPRD ID		01769	01903
Ensembl ID			ENSG00000138448
Uniprot IDs		B0YJA4 P04216	B7ZLX0 P06756
PDB IDs			1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Blood Coagulation Hemostasis Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Wound Healing Response To Wounding Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Cell Migration Homotypic Cell-cell Adhesion Cell Motility Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Integrin-mediated Signaling Pathway Regulation Of Lipoprotein Metabolic Process Cell Adhesion Locomotion Negative Regulation Of Macrophage Derived Foam Cell Differentiation Viral Process Regulation Of Receptor Biosynthetic Process Negative Regulation Of Lipid Storage Negative Chemotaxis Activated T Cell Proliferation Chemotaxis Heterotypic Cell-cell Adhesion Platelet Activation Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Negative Regulation Of Lipid Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Defense Response To Virus By Virus Response To External Stimulus T Cell Aggregation T Cell Activation Lymphocyte Aggregation Peptidyl-tyrosine Autophosphorylation Leukocyte Aggregation Viral Entry Into Host Cell Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Leukocyte Cell-cell Adhesion	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis
Tagcloud ?		abnormality autologous bm cd19 cd3 cd33 cd34 cd56 cd7 cfu clarified conclusively cytopenia dysplastic erythroblasts erythrocyte gemm granulocyte granulocytes lineages megakaryocyte nk pluripotent progenitor smears sorted sorting subpopulations trisomy	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Difference) ?		abnormality autologous bm cd19 cd3 cd33 cd34 cd56 cd7 cfu clarified conclusively cytopenia dysplastic erythroblasts erythrocyte gemm granulocyte granulocytes lineages megakaryocyte nk pluripotent progenitor smears sorted sorting subpopulations trisomy	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Intersection) ?