THY1 and CCR8

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		THY1	CCR8
Name		Thy-1 cell surface antigen	C-C motif chemokine receptor 8
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Dendrite Growth Cone Axolemma Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome Side Of Membrane Presynapse Postsynapse Glutamatergic Synapse	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding GPI Anchor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Regulation Of Immune System Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Cell Adhesion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Migration Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Positive Regulation Of Cell Adhesion Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion	Chemotaxis Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Chemokine receptors bind chemokines G alpha (i) signalling events
GWAS		Refractive error ( 32231278 )	Daytime sleep phenotypes ( 27126917 ) Medication use (thyroid preparations) ( 31015401 )
Interacting Genes		10 interacting genes: ATXN1L ATXN7 CCR8 CLK1 FYN HTR6 ITGAM ITGAV ITGB3 LCK	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		7070	1237
HPRD ID		01769	03497
Ensembl ID		ENSG00000154096	ENSG00000179934
Uniprot IDs		B0YJA4 J3QRJ3 P04216	P51685
PDB IDs		Not available	8KFX 8KFY 8KFZ 8TLM 8U1U 8XML
GO Terms Enriched among Interactors		Integrin Complex Heterotypic Cell-cell Adhesion Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Non-membrane Spanning Protein Tyrosine Kinase Activity CD8 Receptor Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cell Migration Coreceptor Activity Cell Motility CD4 Receptor Binding Phospholipase Activator Activity T Cell Receptor Binding Integrin-mediated Signaling Pathway Negative Regulation Of Low-density Lipoprotein Particle Clearance Insulin-like Growth Factor I Binding Positive Regulation Of Osteoblast Proliferation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cell-matrix Adhesion Regulation Of Lipoprotein Metabolic Process External Side Of Plasma Membrane Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol 3-kinase Binding Negative Regulation Of Lipoprotein Particle Clearance Protein Tyrosine Kinase Activity Filopodium Membrane Regulation Of Low-density Lipoprotein Particle Clearance Phospholipase Binding Cellular Response To Platelet-derived Growth Factor Stimulus Negative Regulation Of Lipid Storage Fibroblast Growth Factor Binding Integrin Binding Response To Platelet-derived Growth Factor Cell-substrate Adhesion Lamellipodium Membrane Apoptotic Cell Clearance Positive Regulation Of Protein Targeting To Membrane Microvillus Membrane Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Adhesion Fibronectin Binding Wound Healing, Spreading Of Cells Regulation Of Osteoblast Proliferation Extracellular Matrix Binding Regulation Of Protein Targeting To Membrane	Chemokine Activity Eosinophil Migration Eosinophil Chemotaxis Protein-tyrosine Sulfotransferase Activity Cytokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell-cell Signaling Signaling Cell Communication Axolemma Cell Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Negative Regulation Of Neuron Projection Regeneration 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Granulocyte Migration Positive Regulation Of Calcium Ion Transport Humoral Immune Response Positive Regulation Of Transport Golgi Apparatus Gamma-aminobutyric Acid Signaling Pathway Myeloid Leukocyte Migration Chemotaxis Leukocyte Chemotaxis Regulation Of Neuron Projection Regeneration Locomotion Positive Regulation Of Leukocyte Migration Synaptic Transmission, GABAergic Extracellular Space Maintenance Of Mitochondrion Location Regulation Of Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Peptidyl-tyrosine Sulfation N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Calcium-dependent ATPase Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Signal Transduction Relaxation Of Skeletal Muscle H Zone Regulation Of Calcium Ion Transport Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Dimeric Complex