CCNB1 and UBE3C

Number of citations of the paper that reports this interaction (PubMedID 26389696)
53

Data Source:
BioGRID (enzymatic study)

		CCNB1	UBE3C
Description		cyclin B1	ubiquitin protein ligase E3C
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GO Annotations	Cellular Component	Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Cyclin B1-CDK1 Complex	Proteasome Complex
	Molecular Function	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Toxic Substance Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Autophagosome Assembly Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K48-linked Ubiquitination
Pathways		E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerization of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2 Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)
Interacting Genes		64 interacting genes: ANAPC11 ARID4A BRCA1 BTG2 CCNB1IP1 CCNF CDC25A CDC25C CDC34 CDC6 CDH1 CDK1 CDKN1A CDKN1B CDT1 CEBPA CSNK2B CUX1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 KPNB1 MAP4 MEF2C MOK NACC1 OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 PRC1 PRKDC PTCH1 PTMA RALBP1 RB1 RUNX2 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D UCHL3 USP39 WEE1 XIAP XRCC6 ZFAND5	17 interacting genes: APP BIRC6 CAND2 CCNB1 DOT1L GOLGA2 GRSF1 MTA2 PIK3C3 PSMC5 PSMD2 TLK1 TP73 UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		891	9690
HPRD ID		00454	15604
Ensembl ID		ENSG00000134057	ENSG00000009335
Uniprot IDs		P14635	Q15386
PDB IDs		2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 7NJ0 8TAR 8TAU 9FH9	6K2C
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Nucleoplasm Nucleus Regulation Of Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Replication Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Signal Transduction In Response To DNA Damage Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Positive Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Cell Division DNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of DNA Metabolic Process Cyclin Binding Regulation Of Kinase Activity DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Protein Modification Process Proteolysis Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Positive Regulation Of Protein Metabolic Process Protein Tetramerization Post-translational Protein Modification Transferase Activity Proteasome Accessory Complex Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus ATP Binding Catabolic Process TBP-class Protein Binding Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Spindle Pole Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex DNA-binding Transcription Factor Binding Protein K11-linked Ubiquitination
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