CCNB1 and ITPR1

Number of citations of the paper that reports this interaction (PubMedID 16237118)
0

Data Source:
HPRD (in vitro)

		CCNB1	ITPR1
Description		cyclin B1	inositol 1,4,5-trisphosphate receptor type 1
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Membrane Cyclin B1-CDK1 Complex	Nuclear Envelope Nuclear Inner Membrane Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Cytoplasmic Vesicle Protein-containing Complex Synapse Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Patched Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Ubiquitin-like Protein Ligase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding Monoatomic Ion Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding Calcium Ion Transmembrane Transporter Activity Intracellularly Gated Calcium Channel Activity Calcium Channel Inhibitor Activity Protein Domain Specific Binding Phosphatidylinositol Binding Protein Homodimerization Activity Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Spermatogenesis Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Toxic Substance Negative Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA 3'-end Processing Tissue Regeneration Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Protein-containing Complex Assembly Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport	Cell Morphogenesis Response To Hypoxia Monoatomic Ion Transport Calcium Ion Transport Apoptotic Process Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Single Fertilization Post-embryonic Development Regulation Of Autophagy Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Import Into The Mitochondrion Epithelial Fluid Transport Positive Regulation Of Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Ligand-gated Ion Channel Signaling Pathway
Pathways		E2F-enabled inhibition of pre-replication complex formation Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdc20 mediated degradation of Cyclin B Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes MASTL Facilitates Mitotic Progression Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Depolymerization of the Nuclear Lamina TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Mitotic Prophase Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional regulation by RUNX2 Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in cell cycle and proliferation	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Femur bone mineral density x serum urate levels interaction ( 34046847) Gamma glutamyl transferase levels ( 29403010 33339817) Hand grip strength ( 29691431) HDL cholesterol levels in HIV infection ( 33109212) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32154731 32203549) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		64 interacting genes: ANAPC11 ARID4A BRCA1 BTG2 CCNB1IP1 CCNF CDC25A CDC25C CDC34 CDC6 CDH1 CDK1 CDKN1A CDKN1B CDT1 CEBPA CSNK2B CUX1 EP300 FLNA FZR1 GADD45A GADD45B GADD45G H1-1 H1-5 HERC5 ITPR1 KAT5 KPNB1 MAP4 MEF2C MOK NACC1 OGT OTUD7B PBK PCNA PIN1 PKMYT1 PLK1 PRC1 PRKDC PTCH1 PTMA RALBP1 RB1 RUNX2 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 TULP3 UBE2D2 UBE2N UBE3C UBE3D UCHL3 USP39 WEE1 XIAP XRCC6 ZFAND5	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		891	3708
HPRD ID		00454	00925
Ensembl ID		ENSG00000134057	ENSG00000150995
Uniprot IDs		P14635	B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs		2B9R 2JGZ 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 7NJ0 8TAR 8TAU 9FH9
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Nucleoplasm Nucleus Regulation Of Protein Modification Process Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Replication Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of DNA Replication Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Signal Transduction In Response To DNA Damage Regulation Of Phosphorus Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Phosphorylation Positive Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Cell Division DNA Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of DNA Metabolic Process Cyclin Binding Regulation Of Kinase Activity DNA Damage Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Intracellular Signal Transduction Signal Transduction G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Response To Metal Ion Regulation Of Transport Regulation Of Cell Communication Regulation Of Cellular Localization Regulation Of Signal Transduction Regulation Of Signaling G Protein-coupled Glutamate Receptor Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Muscle System Process Glutamate Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Protein Phosphorylation Response To Calcium Ion Calcium Ion Transport Phosphorylation Regulation Of Monoatomic Cation Transmembrane Transport Plasma Membrane Negative Regulation Of Signal Transduction Glutamatergic Synapse Regulation Of System Process Negative Regulation Of Multicellular Organismal Process Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Hydrogen Peroxide Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inositol 1,4,5 Trisphosphate Binding Calcium Ion Transmembrane Transport Regulation Of Store-operated Calcium Entry Regulation Of Cell Activation Negative Regulation Of Apoptotic Process Lymphocyte Proliferation Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Calcium Ion Homeostasis Mononuclear Cell Proliferation Protein Kinase Activity
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