CCNB1 and CCNF

Number of citations of the paper that reports this interaction (PMID 10716937)
23

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CCNB1	CCNF
Gene Name		cyclin B1	cyclin F
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane	Nucleus Centriole SCF Ubiquitin Ligase Complex
	Molecular Function	Patched Binding Protein Binding Protein Kinase Binding Histone Kinase Activity	Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Protein Complex Assembly Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Spindle Stabilization Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Histone H3-S10 Phosphorylation Involved In Chromosome Condensation	Re-entry Into Mitotic Cell Cycle Placenta Development Mitotic Nuclear Division Negative Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		Phosphorylation of the APC/C MASTL Facilitates Mitotic Progression Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Phosphorylation of Emi1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes E2F mediated regulation of DNA replication G2/M DNA damage checkpoint Depolymerisation of the Nuclear Lamina Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic APC/C:Cdc20 mediated degradation of Cyclin B Resolution of Sister Chromatid Cohesion E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC6 CDK1 CDK7 CDKN1A CDKN1B CDT1 CKS2 EP300 FLNA FZR1 GADD45A GADD45B GADD45G HERC5 HIST1H1A HIST1H1B ITPR1 KAT5 MAP4 MEF2C MOK PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PSMD4 PTCH1 PTMA RAD23A RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE3D UBQLN1	1 interactors: CCNB1
Entrez ID		891	899
HPRD ID		00454	02574
Ensembl ID		ENSG00000134057	ENSG00000162063
Uniprot IDs		P14635 Q5TZP9	P41002 Q59HD0
PDB IDs		2B9R 2JGZ
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Checkpoint Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Cell Division Organelle Organization Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition	Response To DDT Histone H3-S10 Phosphorylation Involved In Chromosome Condensation Cellular Response To Iron(III) Ion Mitotic Spindle Stabilization Regulation Of Chromosome Condensation Histone H3-S10 Phosphorylation Response To Iron(III) Ion Spindle Stabilization Positive Regulation Of Histone Phosphorylation Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Iron Ion Regulation Of Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Chromosome Segregation Regulation Of MRNA 3'-end Processing Response To Insecticide Ventricular Cardiac Muscle Cell Development Histone-serine Phosphorylation Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Spindle Checkpoint Oocyte Maturation Mitotic Metaphase Plate Congression Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Metaphase Plate Congression Mitotic Nuclear Envelope Disassembly Negative Regulation Of Microtubule Depolymerization Response To Iron Ion Regulation Of Cell Cycle Checkpoint Positive Regulation Of Heart Growth Histone Phosphorylation Nuclear Envelope Disassembly Establishment Of Chromosome Localization Cellular Response To Fatty Acid Regulation Of Cardiac Muscle Cell Proliferation Oocyte Development Oocyte Differentiation Negative Regulation Of Microtubule Polymerization Or Depolymerization Chromosome Condensation Positive Regulation Of Organ Growth Tissue Regeneration Regulation Of Heart Growth Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Cardiac Muscle Tissue Development Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Nuclear Envelope Organization
Tagcloud ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac	atxn2 bid cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1
Tagcloud (Difference) ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas subcloning syntenic uncharacterized yac	atxn2 bid cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1
Tagcloud (Intersection) ?		smn