CCNB1 and CDC6

Number of citations of the paper that reports this interaction (PMID 10339564)
62

Data Source:
BioGRID (enzymatic study)

		CCNB1	CDC6
Gene Name		cyclin B1	cell division cycle 6
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Spindle Midzone
	Molecular Function	Patched Binding Protein Binding Protein Kinase Binding Histone Kinase Activity	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Oocyte Maturation In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Protein Complex Assembly Mitotic Nuclear Envelope Disassembly Mitotic Metaphase Plate Congression Spermatogenesis Response To Mechanical Stimulus Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone Phosphorylation Tissue Regeneration Response To Drug Mitotic Spindle Stabilization Positive Regulation Of Mitotic Cell Cycle Response To DDT Positive Regulation Of Fibroblast Proliferation Digestive Tract Development Cell Division Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Chromosome Condensation Cellular Response To Iron(III) Ion Cellular Response To Fatty Acid Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Histone H3-S10 Phosphorylation Involved In Chromosome Condensation	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Cell Division Positive Regulation Of Chromosome Segregation
Pathways		Phosphorylation of the APC/C MASTL Facilitates Mitotic Progression Mitotic Prometaphase G2/M Checkpoints Mitotic Prophase Golgi Cisternae Pericentriolar Stack Reorganization Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Envelope Breakdown G2/M Transition Phosphorylation of Emi1 Recruitment of NuMA to mitotic centrosomes Regulation of PLK1 Activity at G2/M Transition M Phase Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Mitotic G1-G1/S phases Recruitment of mitotic centrosome proteins and complexes G2/M DNA replication checkpoint Condensation of Prometaphase Chromosomes E2F mediated regulation of DNA replication G2/M DNA damage checkpoint Depolymerisation of the Nuclear Lamina Nuclear Pore Complex (NPC) Disassembly APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic APC/C:Cdc20 mediated degradation of Cyclin B Resolution of Sister Chromatid Cohesion E2F-enabled inhibition of pre-replication complex formation Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints Centrosome maturation Condensation of Prophase Chromosomes Mitotic G2-G2/M phases Polo-like kinase mediated events	CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition G0 and Early G1 S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ANAPC11 ARID4A BRCA1 CCNB1IP1 CCNF CDC20 CDC25A CDC25C CDC27 CDC6 CDK1 CDK7 CDKN1A CDKN1B CDT1 CKS2 EP300 FLNA FZR1 GADD45A GADD45B GADD45G HERC5 HIST1H1A HIST1H1B ITPR1 KAT5 MAP4 MEF2C MOK PBK PCNA PIN1 PKMYT1 PLK1 POLA1 PRC1 PSMD4 PTCH1 PTMA RAD23A RALBP1 RB1 RPA1 RUNX2 SQSTM1 TGFBR2 TP53BP1 TP73 TSC1 TSPYL2 UBE2D2 UBE3D UBQLN1	36 interactors: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A TERF1 UBE2K UBR1
Entrez ID		891	990
HPRD ID		00454	04022
Ensembl ID		ENSG00000134057	ENSG00000094804
Uniprot IDs		P14635 Q5TZP9	Q99741
PDB IDs		2B9R 2JGZ	2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Cell Cycle Checkpoint Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Cell Division Organelle Organization Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication DNA Metabolic Process Regulation Of Cell Cycle DNA Replication Initiation Cell Cycle Checkpoint DNA-dependent DNA Replication Negative Regulation Of Cell Cycle Cell Division Cellular Metabolic Process Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Checkpoint Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Transition Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Cellular Response To Stress Cellular Response To DNA Damage Stimulus Cellular Protein Modification Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process
Tagcloud ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac	antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Difference) ?		5q13 bacs bacterium chosen contig copy flanking hope inherited intricate legionella lgn1 map1b mapped maps muscular naip p1s pathogenicity pneumophila recessively simpler sma smas smn subcloning syntenic uncharacterized yac	antiserum cdc18p cdc6p cerevisiae cloning cooperates cotransfection downregulating dsc1 e2f enter eukaryotes exponentially footprinting hcdc6 homolog mbf microinjection multicellular occupied pombe prb prereplication replication resting saccharomyces sbf schizosaccharomyces timed
Tagcloud (Intersection) ?