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CCNB1 and TP53BP1
Number of citations of the paper that reports this interaction (PubMedID
20126263
)
109
Data Source:
BioGRID
(enzymatic study)
CCNB1
TP53BP1
Description
cyclin B1
tumor protein p53 binding protein 1
Image
GO Annotations
Cellular Component
Spindle Pole
Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Membrane
Cyclin B1-CDK1 Complex
Chromosome, Centromeric Region
Kinetochore
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Cytoplasm
Nuclear Body
Site Of Double-strand Break
DNA Repair Complex
Molecular Function
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
P53 Binding
DNA Binding
Damaged DNA Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
Telomeric DNA Binding
Histone Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin-modified Histone Reader Activity
Histone H4K20me2 Reader Activity
Histone Reader Activity
Histone H4K20me Methyltransferase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Mitotic Spindle Organization
Mitotic Metaphase Chromosome Alignment
Spermatogenesis
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Toxic Substance
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of MRNA 3'-end Processing
Tissue Regeneration
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
DNA Damage Checkpoint Signaling
DNA Repair
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Positive Regulation Of Isotype Switching
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Protein Homooligomerization
Cellular Response To X-ray
Double-strand Break Repair Via Classical Nonhomologous End Joining
DNA Strand Resection Involved In Replication Fork Processing
Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Protein Localization To Site Of Double-strand Break
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerization of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Nuclear events stimulated by ALK signaling in cancer
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
SUMOylation of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Antibody level in response to infection (
25758998
)
Apolipoprotein A1 levels (
32203549
)
Cardiometabolic and hematological traits (
27668658
)
Eosinophil count (
32888494
)
HDL cholesterol levels (
32203549
30698716
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Lipoprotein phospholipase A2 activity in cardiovascular disease (
28753643
)
Liver volume (
34128465
)
Lung cancer in ever smokers (
28604730
)
Mean corpuscular volume (
32888494
)
Triglyceride levels (
30698716
)
Triglyceride levels in current drinkers (
30698716
)
Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Triglycerides (
27036123
)
Interacting Genes
64 interacting genes:
ANAPC11
ARID4A
BRCA1
BTG2
CCNB1IP1
CCNF
CDC25A
CDC25C
CDC34
CDC6
CDH1
CDK1
CDKN1A
CDKN1B
CDT1
CEBPA
CSNK2B
CUX1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
KPNB1
MAP4
MEF2C
MOK
NACC1
OGT
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
PRC1
PRKDC
PTCH1
PTMA
RALBP1
RB1
RUNX2
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2D2
UBE2N
UBE3C
UBE3D
UCHL3
USP39
WEE1
XIAP
XRCC6
ZFAND5
60 interacting genes:
ANKS1A
ARAP1
ATM
BCL6
BLM
BRCA1
BRCA2
C10orf55
CCDC120
CCNB1
CDK1
CEBPA
CHEK1
CRB2
CREB5
DCLRE1A
DCLRE1C
DYNLL1
E2F1
EP300
GALNTL5
H2AC4
H2AX
H4C1
H4C14
H4C16
HGS
IFI16
KAT8
KDM1A
KLHDC7B
LIG4
MDC1
MEOX2
NCOA3
NEK1
NFKB1
NUDT16
OXER1
PARP1
PAXIP1
PCNT
PITX1
POU6F2
PTEN
RAD18
RAD50
RAD51
RBL1
RBL2
RELA
SPAG9
SPOP
SUMO2
TFDP1
TLX3
TP53
UBAP2
USP28
VAC14
Entrez ID
891
7158
HPRD ID
00454
05569
Ensembl ID
ENSG00000134057
ENSG00000067369
Uniprot IDs
P14635
A6NNK5
Q12888
PDB IDs
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
7NJ0
8TAR
8TAU
9FH9
1GZH
1KZY
1XNI
2G3R
2IG0
2LVM
2MWO
2MWP
3LGF
3LGL
3LH0
4CRI
4RG2
4X34
5ECG
5J26
5KGF
5Z78
5ZCJ
6CO1
6CO2
6IU7
6IUA
6MXX
6MXY
6MXZ
6MY0
6RML
6RMM
6UPT
6VA5
6VIP
7LIN
7LIO
7YQK
8EOM
8F0W
8HKW
8SVG
8SVH
8SVI
8SVJ
8SWJ
8T2D
8U4U
9CKJ
Enriched GO Terms of Interacting Partners
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Regulation Of Cell Cycle
Nucleoplasm
Nucleus
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Negative Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Replication
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of DNA Replication
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Modification Process
Signal Transduction In Response To DNA Damage
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Phosphorylation
Positive Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
Cell Division
DNA Metabolic Process
Regulation Of Protein Kinase Activity
Negative Regulation Of DNA Metabolic Process
Cyclin Binding
Regulation Of Kinase Activity
DNA Damage Response
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Ionizing Radiation
Chromatin Organization
Chromosome
Regulation Of Cell Cycle Phase Transition
DNA Damage Response
Chromosome, Telomeric Region
Regulation Of Cell Cycle Process
Nucleoplasm
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle Phase Transition
Chromatin Remodeling
Negative Regulation Of Cell Cycle
DNA Repair
Signal Transduction In Response To DNA Damage
DNA Metabolic Process
Regulation Of Cell Cycle
Cellular Response To Radiation
DNA Binding
Response To Radiation
DNA Damage Checkpoint Signaling
Regulation Of DNA Recombination
Cellular Response To Ionizing Radiation
Protein Localization To Chromosome
Cellular Response To Stress
Negative Regulation Of Mitotic Cell Cycle
Regulation Of DNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Double-strand Break Repair
Telomere Organization
DNA Recombination
Nucleus
Transcription Regulator Complex
Site Of Double-strand Break
Protein-containing Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Nucleic Acid Metabolic Process
Chromosome Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Chromatin
Regulation Of Cell Cycle G2/M Phase Transition
Response To X-ray
Regulation Of Macromolecule Metabolic Process
Response To Gamma Radiation
Replication Fork
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Primary Metabolic Process
Signal Transduction By P53 Class Mediator
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Tagcloud (Intersection)
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