SMAD7 and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 16601693)
48

Data Source:
HPRD (in vitro, in vivo)

		SMAD7	AXIN1
Description		SMAD family member 7	axin 1
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Cell Periphery Wnt Signalosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding I-SMAD Binding Activin Receptor Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity	P53 Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding Protein Serine/threonine Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Protein-containing Complex Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Protein-containing Complex Disassembly Adherens Junction Assembly Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Differentiation Artery Morphogenesis Protein Stabilization Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Beta-catenin Destruction Complex Disassembly Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Protein Polyubiquitination In Utero Embryonic Development Nucleocytoplasmic Transport Apoptotic Process Sensory Perception Of Sound Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Negative Regulation Of Gene Expression Wnt Signaling Pathway Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Post-anal Tail Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of JNK Cascade Axial Mesoderm Development Axial Mesoderm Formation Cell Development Negative Regulation Of Protein Metabolic Process Canonical Wnt Signaling Pathway Head Development Regulation Of Canonical Wnt Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases Interferon gamma signaling	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Caudal duplication anomaly Hepatocellular carcinoma
GWAS		Asthma ( 32296059) Atrial fibrillation ( 29892015 30061737) Colorectal cancer ( 24836286 29471430 29228715 17934461 30529582 26151821 25990418 24448986 23266556 31826910 21761138 18372905 18372901) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Waist circumference ( 31928498)
Interacting Genes		58 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L PARD3 PIAS1 PIAS4 RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 USP2 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	91 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 FXR1 FXR2 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KAT5 KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RCHY1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSC1 TSGA10 UCHL5 USP10 USP7 UTP14A WSB1 ZBTB26 ZFYVE19
Entrez ID		4092	8312
HPRD ID		04241	04819
Ensembl ID		ENSG00000101665	ENSG00000103126
Uniprot IDs		B3KYA8 O15105	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ 6JCK 7SXF 7SXG 7SXH 7SXJ 7Y1P 8RU3 8RU4 8VMG
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Binding Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication	Wnt Signaling Pathway Cytoplasm Cytosol Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Wnt Signalosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Post-translational Protein Modification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Component Organization Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Beta-catenin Destruction Complex Signal Transduction Beta-catenin Binding PML Body Positive Regulation Of Biosynthetic Process
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