SMAD7 and HEYL

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SMAD7	HEYL
Gene Name		SMAD family member 7	hes-related family bHLH transcription factor with YRPW motif-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Catenin Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Protein Homodimerization Activity Protein Heterodimerization Activity AF-1 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein Complex Localization Intracellular Signal Transduction Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus	Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Pulmonary Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Mesenchymal Cell Development Glomerulus Development Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To BMP Stimulus Proximal Tubule Development Negative Regulation Of Androgen Receptor Activity
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Colorectal cancer ( 18372901 18372905 21761138 17934461 23266556) Dental caries ( 23064961) Inflammatory bowel disease ( 23128233)	Red blood cell traits ( 23222517)
Protein-Protein Interactions		54 interactors: ACVR1B AKT1 ASH1L AXIN1 BMPR1B CTNNB1 CXXC5 DVL1 EP300 ERBB2IP HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MKL2 MYOD1 NEDD4L PARD3 PARD3B PIAS1 PIAS4 RNF111 SASH3 SIRT1 SMAD2 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	18 interactors: APP ATF7IP ATXN1 HAND1 HAND2 HIPK3 HTT LAPTM5 MDFI PPP1CA RBPMS RPGRIP1 SKIL SMAD3 SMAD7 SMAD9 SP8 ZNF512B
Entrez ID		4092	26508
HPRD ID		04241	16419
Ensembl ID		ENSG00000101665	ENSG00000163909
Uniprot IDs		B3KYA8 O15105	F5H3V9 Q9NQ87
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression RNA Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Tissue Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression	Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Anatomical Structure Morphogenesis RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Tube Development Epithelium Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Negative Regulation Of Signaling Regulation Of Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Macromolecule Biosynthetic Process Tissue Development Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Signaling Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cardiac Right Ventricle Formation Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Organ Morphogenesis Negative Regulation Of DNA Binding Embryonic Morphogenesis System Development
Tagcloud ?		adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected ribose shheyl silence sk split surgically yrpw
Tagcloud (Difference) ?		adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate	bad bromide cancerous dimethylthiazol diphenyltetrazolium egfp eighty expressional hairy hcc hep hypermethylation inactivated lentiviral overexpress p19 pheyl preceded qpcr repressor resected shheyl silence sk split surgically yrpw
Tagcloud (Intersection) ?		ribose