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SMAD7 and YAP1
Number of citations of the paper that reports this interaction (PubMedID
12118366
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
SMAD7
YAP1
Description
SMAD family member 7
Yes1 associated transcriptional regulator
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Membrane
Cell Junction
Anchoring Junction
TEAD-YAP Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
I-SMAD Binding
Activin Receptor Binding
Transcription Regulator Inhibitor Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Proline-rich Region Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Protein-containing Complex Localization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Activin Receptor Signaling Pathway
Protein-containing Complex Disassembly
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Differentiation
Artery Morphogenesis
Protein Stabilization
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Beta-catenin Destruction Complex Disassembly
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Blastocyst Development
Trophectodermal Cell Differentiation
Tissue Homeostasis
Glandular Epithelial Cell Differentiation
Heart Process
Embryonic Heart Tube Morphogenesis
DNA Damage Response
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Positive Regulation Of Cell Growth
Epithelial Cell Differentiation
Negative Regulation Of Epithelial Cell Differentiation
Polarized Epithelial Cell Differentiation
Notochord Development
Response To Progesterone
Somatic Stem Cell Population Maintenance
Organ Growth
Hippo Signaling
Wound Healing
Regulation Of Cell Population Proliferation
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Organ Growth
Paraxial Mesoderm Development
Lateral Mesoderm Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Positive Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Bud Elongation Involved In Lung Branching
Lung Epithelial Cell Differentiation
Intestinal Epithelial Cell Differentiation
Intestinal Epithelial Cell Development
Regulation Of Canonical Wnt Signaling Pathway
Cardiac Muscle Tissue Regeneration
Canonical Glycolysis
Protein-containing Complex Assembly
Interleukin-6-mediated Signaling Pathway
Cellular Response To Retinoic Acid
Cellular Response To Gamma Radiation
Regulation Of Stem Cell Proliferation
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Cilium Assembly
Positive Regulation Of Stem Cell Population Maintenance
Enterocyte Differentiation
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Interferon gamma signaling
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
RUNX3 regulates YAP1-mediated transcription
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Formation of axial mesoderm
Zygotic genome activation (ZGA)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases
GWAS
Asthma (
32296059
)
Atrial fibrillation (
29892015
30061737
)
Colorectal cancer (
24836286
29471430
29228715
17934461
30529582
26151821
25990418
24448986
23266556
31826910
21761138
18372905
18372901
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Myocardial infarction (
33532862
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Serum alkaline phosphatase levels (
33547301
)
Cleft palate (
27018472
)
Colorectal cancer or advanced adenoma (
30510241
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Heel bone mineral density (
30598549
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Migraine (
27322543
)
Offspring birth weight (
31043758
)
Polycystic ovary syndrome (
22885925
26416764
30566500
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Pulse pressure (
30224653
30578418
)
Reticulocyte count (
32888494
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
58 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
PARD3
PIAS1
PIAS4
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
USP2
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
103 interacting genes:
ABL1
AKT1
AMOT
ANK3
APC2
ARID2
ATN1
BEAN1
CCDC87
CDIP1
CNKSR2
CRTC3
CSNK1D
CSNK1E
DDN
EIF3H
ENAH
ENTREP3
ERBB4
ESS2
FBXW7
FOXI1
FOXJ3
FXR1
GAB1
GAS5
GBF1
GLIS3
HNRNPU
HNRNPUL1
IGSF9B
JCAD
JOSD2
KIF5A
LATS2
LINC00839
MAP2
MAP3K2
MAP3K3
MAPKAPK5
MLANA
MRPL49
MYCT1
NDFIP2
NEK1
NFE2
NHERF1
NR1I2
OTUB1
OTUD1
PIP4P1
PIP4P2
PKNOX2
PRR7
PRRG2
PRRG4
PTCH1
PTEN
PTPN21
RBM14
RHBDD2
RNF11
RNF38
RUNX1
RUNX2
RUNX3
SCAMP3
SCAMP4
SCN1A
SDCBP
SH3D21
SHISA4
SMAD1
SMAD7
SUMO3
TEAD1
TEAD2
TEAD3
TEAD4
TGFB1I1
TMEM139
TMEM151B
TMEM252
TMEM59L
TMEM61
TMEM92
TNRC18
TP53BP2
TP63
TP73
TRERF1
TRIP6
TSPYL2
TTYH3
UBE2L6
UCHL3
UVRAG
WBP1
WBP2
WT1
YWHAG
YWHAQ
YWHAZ
Entrez ID
4092
10413
HPRD ID
04241
09424
Ensembl ID
ENSG00000101665
ENSG00000137693
Uniprot IDs
B3KYA8
O15105
K0KVU2
P46937
PDB IDs
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
1JMQ
1K5R
1K9Q
1K9R
2LAW
2LAX
2LAY
2LTV
2LTW
3KYS
3MHR
4RE1
4REX
5OAQ
5YDX
5YDY
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GE3
6GE4
6GE5
6GE6
6GEC
6GEE
6GEG
6GEI
6GEK
6HIK
6HIL
6Q2X
7O07
8A8Q
8A8R
8C2F
8WRG
9FZA
Enriched GO Terms of Interacting Partners
?
I-SMAD Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
SMAD Binding
Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Developmental Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cell Differentiation
Ubiquitin Protein Ligase Binding
Tissue Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
WW Domain Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Intracellular Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Hippo Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Organ Growth
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Regulation Of Developmental Growth
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Developmental Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Primary Metabolic Process
Sequence-specific Double-stranded DNA Binding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Cell Fate Commitment
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Growth
Regulation Of Cell Cycle
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Chromatin
Positive Regulation Of Signal Transduction
Regulation Of Developmental Process
Regulation Of Gene Expression
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity
Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Cell Communication
Protein Phosphorylation
Regulation Of Mitotic Cell Cycle
Embryonic Organ Development
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Protein Domain Specific Binding
Golgi Localization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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