SMAD7 and ACVR1B

Number of citations of the paper that reports this interaction (PMID 12023024)
4

Data Source:
HPRD (in vivo)

		SMAD7	ACVR1B
Gene Name		SMAD family member 7	activin A receptor, type IB
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Catenin Complex Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Beta-catenin Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Activin Binding I-SMAD Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ureteric Bud Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Assembly Response To Laminar Fluid Shear Stress Cellular Protein Complex Localization Intracellular Signal Transduction Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Artery Morphogenesis Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Signaling by BMP Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL
Drugs			Adenosine triphosphate
Diseases
GWAS		Colorectal cancer ( 18372901 18372905 21761138 17934461 23266556) Dental caries ( 23064961) Inflammatory bowel disease ( 23128233)	Urate levels ( 23263486)
Protein-Protein Interactions		54 interactors: ACVR1B AKT1 ASH1L AXIN1 BMPR1B CTNNB1 CXXC5 DVL1 EP300 ERBB2IP HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MKL2 MYOD1 NEDD4L PARD3 PARD3B PIAS1 PIAS4 RNF111 SASH3 SIRT1 SMAD2 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	20 interactors: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L OS9 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1
Entrez ID		4092	91
HPRD ID		04241	03193
Ensembl ID		ENSG00000101665	ENSG00000135503
Uniprot IDs		B3KYA8 O15105	P36896
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression RNA Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Substance Tissue Development Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Signal Transduction BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cell Communication Positive Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Tissue Morphogenesis Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Mesoderm Development Regulation Of Signaling SMAD Protein Complex Assembly Heart Development Embryo Development Positive Regulation Of Phosphorylation Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?		adp beta1 blocks decapentaplegic deoxynucleotidyl deoxyuridine fibroblasts fibrogenic fibrotic homolog hydroxyproline immunocytochemistry mothers myofibroblasts nick pd peyronie pretreated quashed ribose smad2 smad3 terminate tgf transdifferentiation transferase transforming triphosphate	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?