SMAD7 and KDM2A

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMAD7	KDM2A
Description		SMAD family member 7	lysine demethylase 2A
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex	Nucleus Nucleoplasm Chromosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding I-SMAD Binding Activin Receptor Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Protein-containing Complex Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Protein-containing Complex Disassembly Adherens Junction Assembly Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Differentiation Artery Morphogenesis Protein Stabilization Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Beta-catenin Destruction Complex Disassembly Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation	Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases Interferon gamma signaling	HDMs demethylate histones
Drugs
Diseases
GWAS		Asthma ( 32296059) Atrial fibrillation ( 29892015 30061737) Colorectal cancer ( 24836286 29471430 29228715 17934461 30529582 26151821 25990418 24448986 23266556 31826910 21761138 18372905 18372901) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 28270201 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		58 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L PARD3 PIAS1 PIAS4 RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 USP2 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107	11 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 RELA SMAD3 SMAD7 UBE2G2 ZNF512B
Entrez ID		4092	22992
HPRD ID		04241	05741
Ensembl ID		ENSG00000101665	ENSG00000173120
Uniprot IDs		B3KYA8 O15105	I3VM53 I3VM54 Q9Y2K7
PDB IDs		2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ	2YU1 2YU2 4BBQ 6BYH 6C16 7UV9
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Binding Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication	Transcription Regulator Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding SMAD Protein Signal Transduction Negative Regulation Of MiRNA Transcription Transcription Coactivator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Cellular Response To Growth Factor Stimulus Chromatin Response To Hormone Beta-catenin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Response To Growth Factor I-SMAD Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Chondrocyte Differentiation Double-stranded DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Intracellular Protein Transport Response To Angiotensin Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muscle Stretch Cellular Response To Cytokine Stimulus R-SMAD Binding Regulation Of T-helper 17 Cell Differentiation Intracellular Signaling Cassette Positive Regulation Of Cell Development Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation NF-kappaB Binding Positive Regulation Of Cartilage Development DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Response To Progesterone Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process
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