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SMAD7 and BMPR1B
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
SMAD7
BMPR1B
Description
SMAD family member 7
bone morphogenetic protein receptor type 1B
Image
GO Annotations
Cellular Component
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Protein-containing Complex
Ciliary Basal Body
Heteromeric SMAD Protein Complex
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
HFE-transferrin Receptor Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
I-SMAD Binding
Activin Receptor Binding
Transcription Regulator Inhibitor Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transmembrane Signaling Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
BMP Binding
SMAD Binding
Metal Ion Binding
BMP Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Protein-containing Complex Localization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Activin Receptor Signaling Pathway
Protein-containing Complex Disassembly
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Differentiation
Artery Morphogenesis
Protein Stabilization
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Negative Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Growth Factor Stimulus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Beta-catenin Destruction Complex Disassembly
Cellular Response To Leukemia Inhibitory Factor
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Cartilage Condensation
Ovarian Cumulus Expansion
Osteoblast Differentiation
Eye Development
Chondrocyte Differentiation
Chondrocyte Development
Inflammatory Response
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Dorsal/ventral Pattern Formation
Positive Regulation Of Gene Expression
Central Nervous System Neuron Differentiation
Cell Differentiation
Proteoglycan Biosynthetic Process
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Chondrocyte Differentiation
Ovulation Cycle
Camera-type Eye Development
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Retina Development In Camera-type Eye
Bone Development
Endochondral Bone Morphogenesis
Positive Regulation Of Cartilage Development
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Chondrocyte Proliferation
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Interferon gamma signaling
Signaling by BMP
Drugs
Fostamatinib
Diseases
Acromesomelic dysplasia with genital anomalies
Brachydactyly, including: type A; type B; type D; type E
GWAS
Asthma (
32296059
)
Atrial fibrillation (
29892015
30061737
)
Colorectal cancer (
24836286
29471430
29228715
17934461
30529582
26151821
25990418
24448986
23266556
31826910
21761138
18372905
18372901
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
30604766
31015462
31152163
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Myocardial infarction (
33532862
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Serum alkaline phosphatase levels (
33547301
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Attention deficit hyperactivity disorder (
20732626
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
33020668
)
Diverticular disease (
30177863
)
Haemorrhoidal disease (
33888516
)
Heel bone mineral density (
30598549
)
Hen's egg allergy (
29051540
)
Maximum stenosis (
32469969
)
Opioid dependence (time to event) (
34124712
)
Polycystic ovary syndrome (reproductive subtype) (
32574161
)
Prepulse inhibition of the startle response (
31596458
)
Schizophrenia (
30470734
)
Sum of carotid plaque area (
32469969
)
Sum of stenosis (
32469969
)
Systolic blood pressure (
30578418
30224653
)
Waist-hip ratio (
28552196
)
Interacting Genes
58 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
PARD3
PIAS1
PIAS4
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
USP2
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
64 interacting genes:
AMHR2
APP
ARHGEF6
BAMBI
BMP15
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR2
CDK14
CDK4
CHN1
DCAF12
DCAF6
DCAF7
FANCL
GDF5
GDF6
GDF9
KLHL1
LZTR1
NKIRAS1
OTUB1
OXSR1
PAK1
PLEKHB1
POMK
PPP2CA
PPP3CC
RAB25
RAB38
RAB6B
RAN
RAP2A
RASD2
RASL12
RHEBL1
RHOD
RHOJ
RPS27A
RRAS2
SASH3
SH3KBP1
SMAD6
SMAD7
SNX6
SOCS6
SQSTM1
SRGAP1
STAMBP
STK35
STUB1
TGFBR1
TNNT1
TRAF6
TTC17
TTC27
UBA52
UBE2Z
UBXN1
USP45
VEPH1
Entrez ID
4092
658
HPRD ID
04241
04457
Ensembl ID
ENSG00000101665
ENSG00000138696
Uniprot IDs
B3KYA8
O15105
A8KAE3
O00238
PDB IDs
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
3MDY
Enriched GO Terms of Interacting Partners
?
I-SMAD Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
SMAD Binding
Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Developmental Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of Cell Differentiation
Ubiquitin Protein Ligase Binding
Tissue Development
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Nucleus
Regulation Of Cellular Response To Growth Factor Stimulus
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Communication
Regulation Of SMAD Protein Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cartilage Development
Response To Growth Factor
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cartilage Development
Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Signal Transduction
Cellular Response To BMP Stimulus
GTPase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
GTP Binding
Positive Regulation Of Bone Mineralization
Cardiac Septum Morphogenesis
Ubiquitin Protein Ligase Binding
Regulation Of Ossification
Nucleotide Binding
Positive Regulation Of Biomineral Tissue Development
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Ossification
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Intracellular Signaling Cassette
Regulation Of Osteoblast Differentiation
Mesenchyme Development
BMP Receptor Binding
Transforming Growth Factor Beta Receptor Signaling Pathway
Growth Factor Activity
Negative Regulation Of Signal Transduction
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell Motility
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Locomotion
Intracellular Signal Transduction
Positive Regulation Of Osteoblast Differentiation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Post-translational Protein Modification
Regulation Of Cell Migration
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Tagcloud (Intersection)
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