TFF1 and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFF1	SGTB
Description		trefoil factor 1	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Membrane TRC Complex
	Molecular Function	Protein Binding Growth Factor Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Signal Transduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Iron Ion Cell Differentiation Maintenance Of Gastrointestinal Epithelium Response To Immobilization Stress Response To Peptide Hormone	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Estrogen-dependent gene expression
Drugs		Raloxifene Afimoxifene
Diseases
GWAS		Blood protein levels ( 30072576) Pancreatic cancer ( 22158540)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		20 interacting genes: AKT1 APC ATM BTN3A1 BTNL8 CD300LD ESR2 FCRL4 FGFR2 GKN2 MUC6 RAD51 SGTB SIGLEC8 TSG101 UBQLN1 UBQLN4 VSNL1 XRCC3 ZNF250	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		7031	54557
HPRD ID		00219	18049
Ensembl ID		ENSG00000160182	ENSG00000197860
Uniprot IDs		P04155	Q96EQ0
PDB IDs		1HI7 1PS2 6V1D
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Regulation Of Macroautophagy Response To Alcohol Regulation Of Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Regulation Of Sister Chromatid Segregation Cellular Response To Stress Cellular Response To Decreased Oxygen Levels Protein Autophosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Response To Stress Identical Protein Binding Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Segregation Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nuclear Division Regulation Of Mitotic Nuclear Division Response To X-ray Cellular Response To Gamma Radiation Regulation Of Double-strand Break Repair Recombinational Repair Autophagy Reciprocal Meiotic Recombination Telomere Organization Regulation Of DNA Recombination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Immune Response-activating Signaling Pathway Cellular Response To Oxygen Levels Negative Regulation Of Macroautophagy Regulation Of Protein Catabolic Process Regulation Of Autophagy Macroautophagy Homologous Recombination Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Macromolecule Catabolic Process Regulation Of TRNA Methylation Negative Regulation Of Mitotic Nuclear Division Meiosis I	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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