ORC6 and MCM4

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro)

		ORC6	MCM4
Gene Name		origin recognition complex, subunit 6	minichromosome maintenance complex component 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Plasma Membrane Membrane	Nucleus Nucleoplasm Membrane MCM Complex
	Molecular Function	DNA Binding Protein Binding	Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex	Synthesis of DNA G2/M Checkpoints Activation of the pre-replicative complex DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Activation of the pre-replicative complex Orc1 removal from chromatin S Phase DNA strand elongation Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition Activation of ATR in response to replication stress Cell Cycle Checkpoints Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state Unwinding of DNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	24 interactors: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 SSRP1 SUPT16H TLX2
Entrez ID		23594	4173
HPRD ID		06237	09094
Ensembl ID		ENSG00000091651	ENSG00000104738
Uniprot IDs		Q9Y5N6	B3KMX0 B4DLA6 P33991
PDB IDs		3M03
Enriched GO Terms of Interacting Partners?		DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation DNA-dependent DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Cell Cycle Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Conformation Change Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Replication Checkpoint Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Cellular Response To Stress Regulation Of DNA Replication Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Silencing Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition	DNA Replication G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Process Cell Cycle DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus DNA Repair Chromosome Organization Cellular Response To Stress Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Metabolic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Nucleotide-excision Repair, DNA Gap Filling DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition DNA Recombination DNA Conformation Change Regulation Of Cell Cycle Process Regulation Of DNA Replication DNA Recombinase Assembly Organelle Organization DNA Damage Checkpoint Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Cell Cycle Metabolic Process Response To Stress Positive Regulation Of DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Mitotic Cell Cycle
Tagcloud ?		1br3htert bjhtert cdc6 codepletion collectively deplete depletion diminished dormant dramatically exploited h202 hydroxyurea hypersensitivity hypersensitized licensed licensing maximally modestly nontumor oncogene optimally orc1 origin origins overexpress reliance sensitize viability	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Difference) ?		1br3htert bjhtert cdc6 codepletion collectively deplete depletion diminished dormant dramatically exploited h202 hydroxyurea hypersensitivity hypersensitized licensed licensing maximally modestly nontumor oncogene optimally orc1 origin origins overexpress reliance sensitize viability	adh8l alveolus bmp16 clu1 clu2 coho col1a1 col1a2 cyp19a1a dcn ddit4l droplet fishes fn1 fsh fshr inha ivns1abpa maturing oogenesis perinucleolus pim1 salmon smad5l steroidogenesis suite vitellogenic wapl wt2l
Tagcloud (Intersection) ?