ORC6 and ORC4

Number of citations of the paper that reports this interaction (PubMedID 12614612)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro)

		ORC6	ORC4
Description		origin recognition complex subunit 6	origin recognition complex subunit 4
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GO Annotations	Cellular Component	Origin Recognition Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol Membrane	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication Initiation	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS			Estimated glomerular filtration rate ( 30604766 31015462 31152163) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: APP CDC45 CDC6 CDC7 CEBPA DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4
Entrez ID		23594	5000
HPRD ID		06237	09118
Ensembl ID		ENSG00000091651	ENSG00000115947
Uniprot IDs		Q9Y5N6	A8K7H4 O43929 Q96B14
PDB IDs		3M03 6KVG 8S0B 8S0D	5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Replication CMG Complex Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process MCM Complex Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Origin Recognition Complex Single-stranded DNA Binding Chromosome Double-strand Break Repair DNA Recombination DNA Repair Single-stranded DNA Helicase Activity DNA Damage Response Nucleoplasm Macromolecule Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Helicase Activity Cellular Response To Stress Helicase Activity DNA Replication Preinitiation Complex Regulation Of Primary Metabolic Process Mitotic DNA Replication Initiation ATP Binding Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Cycle Chromatin Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Cycle Response To Stress Regulation Of Metabolic Process ATP Hydrolysis Activity G-rich Strand Telomeric DNA Binding Nucleotide Binding 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication	DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
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