ORC6 and LHX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		ORC6	LHX4
Description		origin recognition complex subunit 6	LIM homeobox 4
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GO Annotations	Cellular Component	Origin Recognition Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol Membrane	Chromatin Nucleus
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication Initiation	Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Refractive error ( 32231278)
Interacting Genes		20 interacting genes: APP CDC45 CDC6 CDC7 CEBPA DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	54 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HNF1B HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NFIC NFIX NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 ZBTB2 ZNF354C ZNF76
Entrez ID		23594	89884
HPRD ID		06237	03686
Ensembl ID		ENSG00000091651	ENSG00000121454
Uniprot IDs		Q9Y5N6	A0A0S2Z5S4 Q969G2
PDB IDs		3M03 6KVG 8S0B 8S0D	5HOD
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Replication CMG Complex Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process MCM Complex Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Origin Recognition Complex Single-stranded DNA Binding Chromosome Double-strand Break Repair DNA Recombination DNA Repair Single-stranded DNA Helicase Activity DNA Damage Response Nucleoplasm Macromolecule Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Helicase Activity Cellular Response To Stress Helicase Activity DNA Replication Preinitiation Complex Regulation Of Primary Metabolic Process Mitotic DNA Replication Initiation ATP Binding Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Cycle Chromatin Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Cycle Response To Stress Regulation Of Metabolic Process ATP Hydrolysis Activity G-rich Strand Telomeric DNA Binding Nucleotide Binding 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication
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