ORC6 and MCM5

Number of citations of the paper that reports this interaction (PubMedID 12614612)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORC6	MCM5
Description		origin recognition complex subunit 6	minichromosome maintenance complex component 5
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GO Annotations	Cellular Component	Origin Recognition Complex Fibrillar Center Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication DNA-templated DNA Replication DNA Replication Initiation	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Drugs
Diseases
GWAS			Chronotype ( 30696823) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: APP CDC45 CDC6 CDC7 CEBPA DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	30 interacting genes: APP ATRIP CDC5L CDC7 CDKN2A CEBPA EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG
Entrez ID		23594	4174
HPRD ID		06237	04075
Ensembl ID		ENSG00000091651	ENSG00000100297
Uniprot IDs		Q9Y5N6	B1AHB0 P33992
PDB IDs		3M03 6KVG 8S0B 8S0D	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Regulation Of DNA Replication CMG Complex Nuclear Origin Of Replication Recognition Complex Nucleic Acid Metabolic Process MCM Complex Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of DNA-templated DNA Replication Initiation Nucleobase-containing Compound Metabolic Process Origin Recognition Complex Single-stranded DNA Binding Chromosome Double-strand Break Repair DNA Recombination DNA Repair Single-stranded DNA Helicase Activity DNA Damage Response Nucleoplasm Macromolecule Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Helicase Activity Cellular Response To Stress Helicase Activity DNA Replication Preinitiation Complex Regulation Of Primary Metabolic Process Mitotic DNA Replication Initiation ATP Binding Regulation Of Macromolecule Metabolic Process Chromatin Binding Regulation Of Cell Cycle Chromatin Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Cycle Response To Stress Regulation Of Metabolic Process ATP Hydrolysis Activity G-rich Strand Telomeric DNA Binding Nucleotide Binding 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication DNA Strand Elongation Involved In DNA Replication	DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex DNA Replication Origin Recognition Complex DNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process DNA Replication Origin Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of Primary Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle DNA Repair Regulation Of Protein Localization To Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition CMG Complex Regulation Of Cell Cycle Chromatin Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Single-stranded DNA Helicase Activity Recombinational Repair Negative Regulation Of Cell Cycle Process Protein Localization To Organelle Mitotic DNA Replication Initiation Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction NF-kappaB Binding Regulation Of Protein Stability Single-stranded DNA Binding Negative Regulation Of DNA-templated Transcription
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