ORC6 and ORC3

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		ORC6	ORC3
Gene Name		origin recognition complex, subunit 6	origin recognition complex, subunit 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Plasma Membrane Membrane	Origin Recognition Complex Nucleoplasm Nuclear Origin Of Replication Recognition Complex
	Molecular Function	DNA Binding Protein Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Neural Precursor Cell Proliferation
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints CDT1 association with the CDC6:ORC:origin complex	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	18 interactors: APP CCNE2 CDC45 CDC6 CDK4 DBF4 HIST3H3 HIST4H4 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 TERF2
Entrez ID		23594	23595
HPRD ID		06237	05398
Ensembl ID		ENSG00000091651	ENSG00000135336
Uniprot IDs		Q9Y5N6	Q9UBD5
PDB IDs		3M03
Enriched GO Terms of Interacting Partners?		DNA Replication G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation DNA-dependent DNA Replication Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Cell Cycle Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Unwinding Involved In DNA Replication DNA Duplex Unwinding DNA Geometric Change Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process DNA Conformation Change Chromosome Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process DNA Replication Checkpoint Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Cell Cycle Cellular Response To Stress Regulation Of DNA Replication Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Gene Silencing Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Replication Initiation Mitotic Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication Cellular Macromolecule Biosynthetic Process DNA Strand Elongation Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cellular Metabolic Process DNA Duplex Unwinding Biosynthetic Process DNA Geometric Change Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Conformation Change Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Telomere Maintenance DNA Replication Checkpoint DNA Unwinding Involved In DNA Replication Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Organelle Organization Regulation Of Mitotic Cell Cycle Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Replication Cell Cycle Checkpoint
Tagcloud ?		1br3htert bjhtert cdc6 codepletion collectively deplete depletion diminished dormant dramatically exploited h202 hydroxyurea hypersensitivity hypersensitized licensed licensing maximally modestly nontumor oncogene optimally orc1 origin origins overexpress reliance sensitize viability
Tagcloud (Difference) ?		1br3htert bjhtert cdc6 codepletion collectively deplete depletion diminished dormant dramatically exploited h202 hydroxyurea hypersensitivity hypersensitized licensed licensing maximally modestly nontumor oncogene optimally orc1 origin origins overexpress reliance sensitize viability
Tagcloud (Intersection) ?