ANG

Description		angiogenin
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Actin Cytoskeleton Endocytic Vesicle Growth Cone Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Nucleic Acid Binding DNA Binding Actin Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity TRNA-specific Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding Hydrolase Activity RRNA Binding Peptide Binding Protein Homodimerization Activity Ribosome Binding Receptor Ligand Activity
	Biological Process	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Response To Yeast Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation Receptor-mediated Endocytosis Cell Communication Signal Transduction RRNA Transcription Response To Hormone TRNA Decay Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Antifungal Humoral Response Signaling Actin Filament Polymerization Cell Differentiation Negative Regulation Of Translation In Response To Stress Cellular Response To Stress Stress Granule Assembly TRNA Stabilization Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Hematopoietic Stem Cell Proliferation
Pathways		Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Blood protein levels ( 30072576)
Interacting Genes		8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 CRIPTO PTEN RNH1 TNFSF8
Entrez ID		283
HPRD ID		00105
Ensembl ID		ENSG00000214274
Uniprot IDs		P03950 W0UV28
PDB IDs		1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V 7NPM 7PNJ 7PNP 7PNR 8AF0 9BDL 9BDN 9BDP
Enriched GO Terms of Interacting Partners?		Filopodium Sarcomere Synapse Actin Filament Titin Z Domain Binding Actin Filament Uncapping Plasma Membrane Apical Plasma Membrane Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Angiogenin-PRI Complex Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Actomyosin Structure Organization Phospholipase C-activating Angiotensin-activated Signaling Pathway Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Ribonuclease Inhibitor Activity Nodal Binding Negative Regulation Of Intestinal Absorption
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