SYNE2

Description		spectrin repeat containing nuclear envelope protein 2
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytoskeleton Plasma Membrane Focal Adhesion Cilium Membrane Sarcoplasmic Reticulum Myofibril Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Actin Binding Protein Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly
Pathways		Meiotic synapsis
Drugs
Diseases		Emery-Dreifuss muscular dystrophy
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 22544366 28416818 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		3 novel interacting genes: ESR2 GLE1 NR2C1
Interacting Genes		12 interacting genes: ABI1 ACTC1 BRAP CALM1 CTNNB1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML RNF10 SASH1
Entrez ID		23224
HPRD ID		09763
Ensembl ID		ENSG00000054654
Uniprot IDs		Q8WXH0
PDB IDs		4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?		Trachea Formation Positive Regulation Of Cell Communication Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Telomere Maintenance Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Nuclear Receptor-mediated Signaling Pathway Animal Organ Formation Regulation Of Nervous System Process Nuclear Steroid Receptor Activity Positive Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signaling Regulation Of Stress-activated MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Lamellipodium Protein Kinase Binding Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cell Communication Regulation Of Calcium Ion Transport Regulation Of Signaling Regulation Of Telomere Maintenance Via Telomerase Thymus Development Glial Cell Fate Determination SMAD Binding Negative Regulation Of Gliogenesis Phosphatase Binding Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Limb Development Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Negative Regulation Of Translation In Response To Oxidative Stress Dendrite Morphogenesis Sarcomere Glutamatergic Synapse Regulation Of System Process
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