SYNE2 and PML

Number of citations of the paper that reports this interaction (PMID 19861416)
13

Data Source:
BioGRID (pull down)

		SYNE2	PML
Gene Name		spectrin repeat containing, nuclear envelope 2	promyelocytic leukemia
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Mitochondrion Focal Adhesion Integral Component Of Membrane Aggresome Sarcoplasmic Reticulum Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane LINC Complex Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Nuclear Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding Protein Heterodimerization Activity Cobalt Ion Binding
	Biological Process	Nuclear Envelope Organization Nuclear Migration Establishment Or Maintenance Of Cell Polarity Fibroblast Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Protein Localization To Nucleus Centrosome Localization Cytoskeletal Anchoring At Nuclear Membrane	Response To Hypoxia Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Protein Targeting Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Histone Deacetylation Negative Regulation Of Telomere Maintenance Via Telomerase Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Negative Regulation Of Translation In Response To Oxidative Stress Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Retinoic Acid Receptor Signaling Pathway Protein Stabilization Maintenance Of Protein Location In Nucleus Defense Response To Virus Negative Regulation Of Telomerase Activity Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Meiotic synapsis	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Atrial fibrillation ( 22544366) Pulmonary function decline ( 22424883)	Height ( 20881960) Myopia (pathological) ( 23049088) Paget's disease ( 21623375)
Protein-Protein Interactions		7 interactors: ACTC1 BRAP CALM1 MAPK3 MAPK8IP2 PML UBC	101 interactors: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RNF4 RPL11 RXRA SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A ZBTB16 ZFYVE9
Entrez ID		23224	5371
HPRD ID		09763	00023
Ensembl ID		ENSG00000054654	ENSG00000140464
Uniprot IDs		Q6MZP0 Q8WXH0	P29590
PDB IDs		4DXS 4FI9	1BOR
Enriched GO Terms of Interacting Partners?		MAPK Cascade Signal Transduction By Phosphorylation Intracellular Signal Transduction Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Defense Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Fibroblast Growth Factor Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Apoptotic Process Toll-like Receptor 5 Signaling Pathway Programmed Cell Death Toll-like Receptor 10 Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Cell Death	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Gene Expression Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Cellular Response To Stimulus Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Response To Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Cell Cycle
Tagcloud ?		ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly	anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast
Tagcloud (Difference) ?		ago1 argonaute cassette chip clusters constitutive crossing deep elongation enhancer enhancers exon explaining implication inclusion intergenic intragenic intronic microrna overlapping paradoxically prominent rather rnai rnas seq sirnas splicing unexpectedly	anthracycline apl approaches appropriately arsenic corepressors curable cure deacetylase effectiveness explain explains incorporation minority oncogenes pathogenetic plzf progranulocytic promoters ra rar recruit refinement relapsed repression safe timed trioxide vast
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