DMTN and CEP76

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DMTN	CEP76
Description		dematin actin binding protein	centrosomal protein 76
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Cytosol Cytoskeleton Actin Filament Plasma Membrane Endomembrane System Postsynaptic Density Spectrin-associated Cytoskeleton Actin Cytoskeleton Membrane Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Cytoplasmic Vesicle Cell Projection Synapse Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Spectrin Binding Actin Filament Binding	Protein Binding
	Biological Process	Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Protein-containing Complex Assembly Cellular Response To CAMP Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Regulation Of Centriole Replication
Pathways		Miscellaneous transport and binding events	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein B levels ( 32203549) Gamma glutamyl transferase levels ( 33339817) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 30275531)
Interacting Genes		16 interacting genes: ACTB ACTC1 APP CEP76 DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB TEX11 TRAF2	105 interacting genes: AKAP7 AKT1 ANKRD36 ASH2L BANP C22orf39 CABP5 CACNB3 CAPN3 CAVIN3 CCDC92 CCNK CDK18 CENPI CIRSR COIL CRYBA4 CSNK1G1 CUTC CWF19L2 DCTD DDX6 DEAF1 DMTN DVL3 DZIP1L EAF1 EIF1AD EP400P1 ERCC3 FAM90A1 GDAP2 GFAP GORASP2 HACL2 HSF2 HSPB7 IQUB KDM1A KDM4D KIAA1143 KIFBP KLHDC4 L3MBTL2 LATS1 LNX1 MAGEA11 MBD3 MFAP1 MISP MLH1 MYOZ1 NEK6 NFYC NHLRC2 NME5 PAICS PARD6B PATZ1 PDGFRB PDRG1 PDZD4 PDZD7 PIN1 PKP1 PLA2G6 PLCB1 POM121 RADIL RALGPS1 RBM41 RIPPLY3 RNF128 RPL9 SALL2 SCNM1 SH2D4A SINHCAF SMG9 SPG21 STK26 SUOX TBC1D27P TCEA2 TCEANC TCF19 TFAP2D THRA TOB2 TSPOAP1 TSSC4 TTC21A TTLL10 TUFT1 TXNDC9 VEZF1 WDFY3 YY1 ZBTB24 ZBTB4 ZMAT2 ZNF185 ZNF653 ZNF76 ZNF85
Entrez ID		2039	79959
HPRD ID		00506	12694
Ensembl ID		ENSG00000158856	ENSG00000101624
Uniprot IDs		Q08495	B4DP81 Q8TAP6
PDB IDs		1QZP 1ZV6
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Transporter Regulator Activity Regulation Of Endocytosis Positive Regulation Of Endocytosis Cytoskeleton Protein-containing Complex Cell Junction Organization Postsynapse Cellular Response To Epinephrine Stimulus Positive Regulation Of Transport Cellular Component Assembly Protein Tetramerization Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Response To Epinephrine Structural Constituent Of Cytoskeleton Actin Cytoskeleton Regulation Of Vesicle-mediated Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Neurotransmitter Uptake Cytoplasm Cytoskeleton Organization Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Regulation Of Metal Ion Transport Regulation Of Generation Of Precursor Metabolites And Energy Cortical Cytoskeleton Regulation Of Synaptic Vesicle Recycling Regulation Of Calcium Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Regulation Of Protein Catabolic Process Amyloid Fibril Formation Microglial Cell Activation Negative Regulation Of Catabolic Process Cell Maturation Positive Regulation Of Small Molecule Metabolic Process Leukocyte Activation Involved In Inflammatory Response Response To Copper Ion Regulation Of Monoatomic Ion Transport Inorganic Ion Homeostasis Cell Cortex Regulation Of Cellular Component Organization Kinesin Binding Protein Kinase Binding Tau Protein Binding Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex	Protein Binding Nucleus
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