ELOB and GHR

Number of citations of the paper that reports this interaction (PubMedID 25505247)
55

Data Source:
BioGRID (unspecified method)

		ELOB	GHR
Description		elongin B	growth hormone receptor
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol VCB Complex Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Transcription Corepressor Binding Protein Binding Ubiquitin Protein Ligase Binding	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly Target-directed MiRNA Degradation	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		23 interacting genes: ASB11 ASB2 ASB8 BRD4 CEBPA CEBPE ELOA ELOA2 ELOA3P ELOC EPOR GHR GPS1 LRRC41 MRPL53 PRAME RACK1 RBX1 SOCS1 SOCS3 SOCS6 VHL ZYG11B	44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		6923	2690
HPRD ID		02874	02971
Ensembl ID		ENSG00000103363	ENSG00000112964
Uniprot IDs		A0A384MDL3 Q15370	A0A087X0H5 A0A087X162 P10912
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7Q 6I7R 6P59 6R6H 6R7F 6R7H 6R7I 6R7N 6SIS 6V9H 6ZHC 7CJB 7JTO 7JTP 7KHH 7M6T 7PI4 7PLO 7Q2J 7S4E 7UPN 7Z6L 7Z76 7Z77 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8CX0 8CX1 8CX2 8EBN 8EI3 8EWV 8FVI 8FVJ 8FY0 8FY1 8FY2 8G1P 8G1Q 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8OEV 8OEW 8OF0 8OKX 8OL1 8P0F 8PC2 8PQL 8Q7R 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8SH2 8SZK 8VL9 8VLB 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 8Y1U 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9D1I 9D1Y 9D1Z 9D8P 9EQJ 9EQM 9IPW	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Metabolic Process Elongin Complex Proteolysis Involved In Protein Catabolic Process Cul2-RING Ubiquitin Ligase Complex Protein Modification Process Macromolecule Metabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Cul5-RING Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT VCB Complex Cell Surface Receptor Signaling Pathway Via STAT Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Macrophage Differentiation Transcription Elongation By RNA Polymerase II Protein Tyrosine Kinase Inhibitor Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Catabolic Process DNA-templated Transcription Elongation Negative Regulation Of Signal Transduction GTPase Inhibitor Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Insulin Receptor Signaling Pathway Interleukin-6-mediated Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Centrosome Duplication	Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm
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