TCEB2 and PRAME

Number of citations of the paper that reports this interaction (PMID 21822215)
9

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TCEB2	PRAME
Gene Name		transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	preferentially expressed antigen in melanoma
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome Elongin Complex	Nucleus Plasma Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Retinoic Acid Receptor Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Viral Process Protein Ubiquitination Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Transcription, DNA-templated Apoptotic Process Positive Regulation Of Cell Proliferation Cell Differentiation Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ASB2 ASB8 CEBPE CUL5 GNB2L1 LRRC41 PRAME RNF7 SOCS1 SOCS3 SOCS6 TCEB1 TCEB3 TCEB3B TCEB3C VHL ZYG11B	9 interactors: CUL2 RARA RBX1 STK19 TCEB1 TCEB2 UBC XRN2 ZNF408
Entrez ID		6923	23532
HPRD ID		02874	05820
Ensembl ID		ENSG00000103363	ENSG00000185686
Uniprot IDs		Q15370	F5H4B1 P78395
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of JAK-STAT Cascade Protein Metabolic Process JAK-STAT Cascade Negative Regulation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Kinase Activity Cellular Metabolic Process Regulation Of JAK-STAT Cascade Regulation Of Growth Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Intracellular Signal Transduction Negative Regulation Of Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Metabolic Process Regulation Of Cellular Process Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Negative Regulation Of Cell Death Regulation Of Type I Interferon-mediated Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Viral Transcription Cellular Protein Catabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Signaling Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase Activity Cellular Response To Peptide Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Response To Insulin Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Viral Process Cellular Macromolecule Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Stress Positive Regulation Of Viral Transcription Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Catabolic Process Transcription Elongation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Protein Modification Process Sertoli Cell Fate Commitment DNA-templated Transcription, Elongation Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Notch Signaling Pathway
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2	aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing ref tab trp tyrosinase uncloned
Tagcloud (Intersection) ?