TCEB2

Gene Name		transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome Elongin Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Viral Process Protein Ubiquitination Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-protein Interactions		17 interactors: ASB2 ASB8 CEBPE CUL5 GNB2L1 LRRC41 PRAME RNF7 SOCS1 SOCS3 SOCS6 TCEB1 TCEB3 TCEB3B TCEB3C VHL ZYG11B
Entrez ID		6923
HPRD ID		02874
Ensembl ID		ENSG00000103363
Uniprot IDs		Q15370
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of JAK-STAT Cascade Protein Metabolic Process JAK-STAT Cascade Negative Regulation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Kinase Activity Cellular Metabolic Process Regulation Of JAK-STAT Cascade Regulation Of Growth Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Intracellular Signal Transduction Negative Regulation Of Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Metabolic Process Regulation Of Cellular Process Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Negative Regulation Of Cell Death Regulation Of Type I Interferon-mediated Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Viral Transcription Cellular Protein Catabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Signaling Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase Activity Cellular Response To Peptide Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Response To Insulin Stimulus
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2