TCEB2 and TCEB3

Number of citations of the paper that reports this interaction (PMID 7660122)
95

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		TCEB2	TCEB3
Gene Name		transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Extracellular Vesicular Exosome Elongin Complex	Extracellular Space Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	DNA Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Gene Expression Viral Process Protein Ubiquitination Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription
Pathways		Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ASB2 ASB8 CEBPE CUL5 GNB2L1 LRRC41 PRAME RNF7 SOCS1 SOCS3 SOCS6 TCEB1 TCEB3 TCEB3B TCEB3C VHL ZYG11B	21 interactors: BRCA1 CEP57L1 CEP70 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SPERT TCEB2 TRIM54
Entrez ID		6923	6924
HPRD ID		02874	02873
Ensembl ID		ENSG00000103363	ENSG00000011007
Uniprot IDs		Q15370	Q14241
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2JZ3 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	4HFX
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of JAK-STAT Cascade Protein Metabolic Process JAK-STAT Cascade Negative Regulation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Kinase Activity Cellular Metabolic Process Regulation Of JAK-STAT Cascade Regulation Of Growth Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Intracellular Signal Transduction Negative Regulation Of Phosphorylation Growth Hormone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Intracellular Signal Transduction Cellular Response To Growth Hormone Stimulus Metabolic Process Regulation Of Cellular Process Negative Regulation Of Insulin Receptor Signaling Pathway Response To Growth Hormone Negative Regulation Of Cell Death Regulation Of Type I Interferon-mediated Signaling Pathway Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Viral Transcription Cellular Protein Catabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Signal Transduction Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Signaling Response To Stress Transcription Elongation From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Peptide Hormone Stimulus Regulation Of Protein Kinase Activity Cellular Response To Peptide Positive Regulation Of CAMP Catabolic Process Regulation Of Cellular Response To Insulin Stimulus	Regulation Of Viral Transcription Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Regulation Of Viral Process Regulation Of Microtubule-based Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Centrosome Duplication Cell Cycle Process Positive Regulation Of Viral Transcription Regulation Of Centrosome Cycle Centrosome Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Microtubule-based Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Centriole Replication Transcription, RNA-templated Positive Regulation Of Histone H3-K9 Acetylation Cell Cycle DNA-templated Transcription, Elongation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Centrosome Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stress Microtubule Organizing Center Organization Embryonic Placenta Development Microtubule Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Transcription, DNA-templated Maintenance Of Protein Location In Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Maintenance Of Protein Location Negative Regulation Of Centriole Replication Positive Regulation Of Centrosome Duplication Maintenance Of Location In Cell Cell Differentiation Regulation Of Cytoskeleton Organization Response To Stress Regulation Of RNA Metabolic Process In Utero Embryonic Development
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib card10 controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome top traf3 trp53bp2	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Intersection) ?