ELOC and ID2

Number of citations: 53 (PubMedID 26735018)
Data Source: BioGRID (pull down)

		ELOC	ID2
Name		elongin C	inhibitor of DNA binding 2
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Transcription Corepressor Binding Protein Binding Protein-macromolecule Adaptor Activity	Transcription Corepressor Activity Protein Binding Transmembrane Transporter Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Target-directed MiRNA Degradation	Negative Regulation Of Transcription By RNA Polymerase II Metanephros Development Natural Killer Cell Differentiation Thigmotaxis Leukocyte Differentiation Membranous Septum Morphogenesis Bundle Of His Development Regulation Of Transcription By RNA Polymerase II Heart Development Circadian Rhythm Adult Locomotory Behavior Entrainment Of Circadian Clock Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Regulation Of Lipid Metabolic Process Olfactory Bulb Development Neuron Differentiation B Cell Differentiation Erythrocyte Differentiation Circadian Regulation Of Gene Expression Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Locomotor Rhythm Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Macrophage Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Cell Development Cell Maturation Rhythmic Process Peyer's Patch Development Embryonic Digestive Tract Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Cell Morphogenesis Involved In Neuron Differentiation Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation White Fat Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Adipose Tissue Development Mammary Gland Alveolus Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Endodermal Digestive Tract Morphogenesis Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Cellular Senescence Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Neural Precursor Cell Proliferation
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	NGF-stimulated transcription
GWAS		No GWAS studies recorded	Alcoholic chronic pancreatitis ( 28754779 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 31959851 27182965 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) IgE levels ( 22075330 ) Itch intensity from mosquito bite ( 28199695 ) Mean corpuscular volume ( 28017375 ) PR interval ( 29127183 30046033 31217584 32439900 ) Self-reported allergy ( 23817569 )
Interacting Genes		40 interacting genes: ASB11 BRD4 CBX5 CEBPA CENPC COMMD1 CPTP CUL2 CUL5 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3P ELOB EPOR GHR ID2 JTB LRRC41 MCM7 MED8 METTL21C MRAS NEURL2 NOTCH4 PRAME RBX1 RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 USP33 USP51 VHL WNT7B ZYG11B	56 interacting genes: ADD1 ANAPC1 ANAPC5 ASB4 C22orf39 CDK1 CDK2 DYRK1A DYRK1B ELK1 ELK3 ELK4 ELOC ENKD1 FANCL FNDC11 FRS3 FZR1 GATA4 GFUS HES1 IFI16 KDM1A LRIF1 MAPK1 MAPK3 MAPK8 MSC MSGN1 MYF5 MYF6 MYOD1 MYOG NEDD9 NR0B2 PAX2 PAX5 PAX8 PICK1 PPP1CA PRMT6 RB1 RBL1 RBL2 RBM48 RHOU RIN3 SREBF1 SUV39H1 SUV39H2 TCF12 TCF3 TCF4 TCHP TNS2 UNC119
Entrez ID		6921	3398
HPRD ID		02875	02664
Ensembl ID		ENSG00000154582	ENSG00000115738
Uniprot IDs		Q15369	Q02363 Q53T66
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6P59 6R7F 6R7H 6R7N 6SIS 6V9H 6ZHC 7CJB 7JTO 7JTP 7KHH 7M6T 7PI4 7PLO 7Q2J 7S4E 7UPN 7Z6L 7Z76 7Z77 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8CX0 8CX1 8CX2 8EBN 8EI3 8EWV 8FVI 8FVJ 8FY0 8FY1 8FY2 8G1P 8G1Q 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8OEV 8OEW 8OF0 8OKX 8OL1 8P0F 8PC2 8PQL 8Q7R 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8SH2 8SZK 8VL9 8VLB 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 8Y1U 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9D1I 9D1Y 9D1Z 9D8P 9EQJ 9EQM 9IPW	4AYA
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Ubiquitination Cul2-RING Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Cul5-RING Ubiquitin Ligase Complex VCB Complex Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Regulation Of Cell Differentiation Macromolecule Catabolic Process Cellular Response To Stress Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Focal Adhesion Disassembly SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Elongin Complex NEDD8 Ligase Activity Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Receptor Signaling Pathway Via JAK-STAT Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via STAT Macromolecule Metabolic Process NEDD8 Transferase Activity Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation	Nucleoplasm Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription E-box Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Skeletal Muscle Fiber Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Skeletal Muscle Fiber Development Skeletal Muscle Cell Differentiation Developmental Process Positive Regulation Of Cell Differentiation Muscle Cell Fate Commitment Regulation Of Lipid Kinase Activity Cellular Response To Starvation RNA Polymerase II-specific DNA-binding Transcription Factor Binding