ELOC and MRAS

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ELOC	MRAS
Name		elongin C	muscle RAS oncogene homolog
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex	Protein Phosphatase Type 1 Complex Plasma Membrane Membrane
	Molecular Function	Transcription Corepressor Binding Protein Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Target-directed MiRNA Degradation	Signal Transduction Ras Protein Signal Transduction Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor
Pathways		Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blond vs. brown/black hair color ( 30531825 ) Body mass index ( 25673413 28448500 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Coronary artery disease ( 24262325 33020668 32469254 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 19198612 ) Daytime nap ( 33568662 ) Diastolic blood pressure ( 27841878 ) Essential hypertension (time to event) ( 32589924 ) Myocardial infarction ( 33532862 ) Systolic blood pressure ( 27841878 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		40 interacting genes: ASB11 BRD4 CBX5 CEBPA CENPC COMMD1 CPTP CUL2 CUL5 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3P ELOB EPOR GHR ID2 JTB LRRC41 MCM7 MED8 METTL21C MRAS NEURL2 NOTCH4 PRAME RBX1 RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 USP33 USP51 VHL WNT7B ZYG11B	11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU
Entrez ID		6921	22808
HPRD ID		02875	06662
Ensembl ID		ENSG00000154582	ENSG00000158186
Uniprot IDs		Q15369	O14807 Q6FGP0 Q8WVM9
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6P59 6R7F 6R7H 6R7N 6SIS 6V9H 6ZHC 7CJB 7JTO 7JTP 7KHH 7M6T 7PI4 7PLO 7Q2J 7S4E 7UPN 7Z6L 7Z76 7Z77 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8CX0 8CX1 8CX2 8EBN 8EI3 8EWV 8FVI 8FVJ 8FY0 8FY1 8FY2 8G1P 8G1Q 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8OEV 8OEW 8OF0 8OKX 8OL1 8P0F 8PC2 8PQL 8Q7R 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8SH2 8SZK 8VL9 8VLB 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 8Y1U 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9D1I 9D1Y 9D1Z 9D8P 9EQJ 9EQM 9IPW	7SD0 7TVF 7TXH 7UPI 9B4R 9B4T 9C1A 9C1B
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Ubiquitination Cul2-RING Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Cul5-RING Ubiquitin Ligase Complex VCB Complex Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Regulation Of Cell Differentiation Macromolecule Catabolic Process Cellular Response To Stress Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Focal Adhesion Disassembly SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Elongin Complex NEDD8 Ligase Activity Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Receptor Signaling Pathway Via JAK-STAT Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via STAT Macromolecule Metabolic Process NEDD8 Transferase Activity Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation	Intracellular Signaling Cassette Signal Transduction Guanyl-nucleotide Exchange Factor Activity ERBB Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Small GTPase Binding Intracellular Signal Transduction Establishment Of Endothelial Intestinal Barrier Face Development Positive Regulation Of Peptidyl-serine Phosphorylation GTP-dependent Protein Binding MAP Kinase Kinase Kinase Activity Response To Muscle Stretch Regulation Of Peptidyl-serine Phosphorylation Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of Cellular Component Organization Thymus Development Regulation Of Protein Modification Process Gland Development Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Regulation Of Small GTPase Mediated Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Insulin Receptor Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Intracellular Glucose Homeostasis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Cellular Component Organization Apoptotic Process Plasma Membrane Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Actin Filament-based Process T Cell Receptor Signaling Pathway Cell Death Hematopoietic Or Lymphoid Organ Development Protein Serine/threonine Kinase Activity Regulation Of Protein Localization Negative Regulation Of Autophagy