TCEB1 and EFNB3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TCEB1	EFNB3
Gene Name		transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	ephrin-B3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol VCB Complex Elongin Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Protein Complex Binding	Transmembrane-ephrin Receptor Activity Ephrin Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Gene Expression Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Viral Process Axon Choice Point Recognition Ephrin Receptor Signaling Pathway
Pathways		Vif-mediated degradation of APOBEC3G Formation of HIV-1 elongation complex containing HIV-1 Tat Cellular response to hypoxia RNA Polymerase II Transcription Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Elongation Class I MHC mediated antigen processing & presentation Host Interactions of HIV factors Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome Adaptive Immune System RNA Polymerase II Transcription Elongation	EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		34 interactors: ASB6 CBX5 CENPC COMMD1 CPTP CUL2 CUL3 CUL5 CYP2J2 ECT2 EFNB3 GNB2L1 JTB LRRC41 MCM7 MED8 METTL21C MRAS NOTCH4 PRAME RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 TCEB2 TCEB3B TCEB3C USP33 VHL WNT7B ZYG11B	7 interactors: AATF EPHA4 EPHB3 P2RX7 RHBDL2 TCEB1 YWHAZ
Entrez ID		6921	1949
HPRD ID		02875	03804
Ensembl ID		ENSG00000154582	ENSG00000108947
Uniprot IDs		Q15369	Q15768
PDB IDs		1LM8 1LQB 1VCB 2C9W 2IZV 3DCG 3ZKJ 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K	4BKF
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Intracellular Signal Transduction Negative Regulation Of JAK-STAT Cascade Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Programmed Cell Death Regulation Of Phosphorylation Cellular Protein Modification Process Cell Death Death Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transferase Activity Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cell Cycle JAK-STAT Cascade Cell Cycle Process Cellular Protein Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Response To Stress Viral Process Regulation Of Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of JAK-STAT Cascade Mitotic Cell Cycle Process Protein Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Interferon-gamma-mediated Signaling Pathway Cell Cycle Phase Transition Cell Morphogenesis Labyrinthine Layer Morphogenesis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Regulation Of Rac GTPase Activity Axonal Fasciculation Regulation Of Rac Protein Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Apoptotic Signaling Pathway Central Nervous System Neuron Axonogenesis Cell Adhesion Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Signaling Pathway Central Nervous System Neuron Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Recognition Positive Regulation Of Cell Death Phospholipid Transfer To Membrane NAD Transport Fasciculation Of Motor Neuron Axon Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Fasciculation Of Sensory Neuron Axon Regulation Of Axonogenesis Phosphorylation Positive Regulation Of Cytolysis Negative Regulation Of Axon Regeneration Golgi Reassembly Multicellular Organismal Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Superoxide Anion Generation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of MAP Kinase Activity Protein Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Histamine Secretion By Mast Cell Central Nervous System Neuron Differentiation Establishment Of Golgi Localization Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Intracellular Transport Apoptotic Process Golgi Inheritance Programmed Cell Death Regulation Of Amyloid Precursor Protein Biosynthetic Process Cellular Response To Stimulus Cell Death Death Cell Morphogenesis Histamine Secretion
Tagcloud ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb2 vhl von	131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l
Tagcloud (Difference) ?		adrenal arise bc chromaffin cnl copy cul2 disrupting elongin enrichment harbored heterozygosity hif1 hif1a hippel hypoxic indeed inherited lindau merit normoxic pcc pheochromocytomas predisposing pseudohypoxic rbx1 tceb2 vhl von	131i anticancer b6 behind destabilization destabilizing egr1 eph epha2 ephb6 ephrin gadd45b lin metaiodobenzylguanidine metformin mibg miz mycn neuregulin nrg1 ntrk1 perp phenformin radiolabeled scintigraphic sel sel1l
Tagcloud (Intersection) ?