BTC and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTC	SGTB
Description		betacellulin	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Membrane TRC Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2-EGFR Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Haemorrhoidal disease ( 33888516) Lung function (FEV1/FVC) ( 30804560)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		685	54557
HPRD ID		02643	18049
Ensembl ID		ENSG00000174808	ENSG00000197860
Uniprot IDs		A0A0S2Z3I5 A0A0S2Z437 P35070	Q96EQ0
PDB IDs		1IOX 1IP0 8U4J 8U4K
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway TRC Complex Epidermal Growth Factor Receptor Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Localization Within Membrane ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation ERBB Signaling Pathway Neuromuscular Junction ERBB4 Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To UV-A Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermis Development Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Programmed Cell Death Protein Targeting To ER Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Establishment Of Protein Localization To Endoplasmic Reticulum Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization To Membrane Basolateral Plasma Membrane Receptor Localization To Synapse Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of ERK1 And ERK2 Cascade Protein Insertion Into Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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