BTC and KRT31

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		BTC	KRT31
Gene Name		betacellulin	keratin 31, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane	Extracellular Space Intermediate Filament Extracellular Vesicular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Structural Constituent Of Cytoskeleton
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Urine Volume Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation	Epidermis Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: EGFR ERBB2 ERBB4 GMPPA KRT31 MMP9	181 interactors: ABI2 AES AGR2 ALDH3B1 ALS2CR11 AMOT AMOTL2 ANKRD36BP1 AQP1 AQP5 ARHGAP35 ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 BEX2 BTC BYSL C12orf49 C19orf73 C1orf109 C1orf216 C5orf60 C6orf165 CA6 CARD9 CARKD CATIP CCDC112 CCDC120 CCDC17 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CEP57 CEP57L1 CEP70 CHCHD2 CHRNG CLDN2 COA5 COMT COX5A COX5B CRH CTSG DGCR6L DHX37 DMRT3 DTNB EIF4E2 EXOC8 FAM103A1 FAM110A FAM124B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FKBP1B FOXB1 GEM GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GPS2 GSTP1 HAUS1 HDAC4 HGS HOXA1 HSPA12B HSPD1 ICAM4 INPP5D INPP5K INSR JOSD1 KIFC3 KLC1 KLC4 KLHL38 KRT2 KRT5 KRT6A KRT6B KRT6C KRT71 KRT77 KRT79 KRT8 KRT81 KRT83 LATS1 LCE4A LENG1 LIN37 LINC00238 LINC00526 LMF2 LMO4 LONRF1 MAP3K7CL MAPKBP1 MARK4 MRPL40 NAV1 NEK6 NPBWR2 OTUB2 P2RX7 PDE4DIP PGLS PIN1 PKN1 PPP1R18 PRF1 PRKAA2 PRR19 PSMA1 PSMG2 PSPC1 PTGER3 PTPMT1 RADIL RCOR3 RIBC1 RPUSD3 RSPH14 SCNM1 SEMA4C SHC3 SIRPA SLC15A3 SLC23A1 SLC25A6 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPON2 SRSF2 SSX2IP TAPBPL THAP7 TMEM106C TMEM231 TMSB4X TRAF4 TROAP TSG101 TTC23 TXLNA USHBP1 UTP23 UXT WDR25 WDYHV1 ZFYVE21 ZNF124 ZNF148 ZNF20 ZNF569 ZNF572 ZNF69 ZNRF2P1
Entrez ID		685	3881
HPRD ID		02643	03047
Ensembl ID			ENSG00000094796
Uniprot IDs		P35070	Q15323
PDB IDs		1IOX 1IP0
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Peptidyl-amino Acid Modification Neuron Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Locomotion Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Axonogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transferase Activity Generation Of Neurons Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Response To Growth Factor Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Neurogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Neuron Projection Morphogenesis Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Cell Development Regulation Of Cellular Component Movement Central Nervous System Morphogenesis Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling	Cellular Process Organelle Organization Epidermis Development Anatomical Structure Development Developmental Process Negative Regulation Of Cellular Metabolic Process Cytoskeleton Organization Positive Regulation Of Urine Volume G2/M Transition Of Mitotic Cell Cycle Gene Expression Regulation Of Body Fluid Levels Epithelium Development RNA Metabolic Process Regulation Of Interleukin-6 Production Carbon Dioxide Transport Response To Organic Substance Regulation Of Glycolytic Process Mitotic Cell Cycle Process Hippo Signaling Negative Regulation Of Biosynthetic Process Positive Regulation Of Interleukin-6 Production Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Stress-activated MAPK Cascade Pancreatic Juice Secretion Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Nuclear Division Regulation Of MAPK Cascade Regulation Of Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Cell Cycle Phase Transition Multicellular Organismal Development Bicarbonate Transport Cell Volume Homeostasis Cell Death Death Interaction With Symbiont Negative Regulation Of Signaling Transcription, DNA-templated Mitotic Cell Cycle Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Fungus Cellular Response To Extracellular Stimulus Cellular Metabolic Process Programmed Cell Death RNA Biosynthetic Process
Tagcloud ?		1000mg 100mg 300mg aes already arm biliary btcs centers endpoint endpoints favored gemcitabine infused intravenously italy m2 monotherapy multicenter nct00753675 orr pfs placebo plus reporting tolerability v vandetanib worsening
Tagcloud (Difference) ?		1000mg 100mg 300mg aes already arm biliary btcs centers endpoint endpoints favored gemcitabine infused intravenously italy m2 monotherapy multicenter nct00753675 orr pfs placebo plus reporting tolerability v vandetanib worsening
Tagcloud (Intersection) ?