BTC and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BTC	KRTAP1-3
Description		betacellulin	keratin associated protein 1-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2-EGFR Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Keratinization
Drugs
Diseases
GWAS		Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Haemorrhoidal disease ( 33888516) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		685	81850
HPRD ID		02643	12305
Ensembl ID		ENSG00000174808	ENSG00000221880
Uniprot IDs		A0A0S2Z3I5 A0A0S2Z437 P35070	Q8IUG1
PDB IDs		1IOX 1IP0 8U4J 8U4K
Enriched GO Terms of Interacting Partners?		ERBB2 Signaling Pathway TRC Complex Epidermal Growth Factor Receptor Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Localization Within Membrane ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation ERBB Signaling Pathway Neuromuscular Junction ERBB4 Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To UV-A Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermis Development Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Programmed Cell Death Protein Targeting To ER Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Establishment Of Protein Localization To Endoplasmic Reticulum Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization To Membrane Basolateral Plasma Membrane Receptor Localization To Synapse Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of ERK1 And ERK2 Cascade Protein Insertion Into Membrane	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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