BTC

Gene Name		betacellulin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Urine Volume Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: EGFR ERBB2 ERBB4 GMPPA KRT31 MMP9
Entrez ID		685
HPRD ID		02643
Ensembl ID
Uniprot IDs		P35070
PDB IDs		1IOX 1IP0
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Peptidyl-amino Acid Modification Neuron Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Locomotion Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Axonogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transferase Activity Generation Of Neurons Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Response To Growth Factor Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Neurogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Neuron Projection Morphogenesis Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Cell Development Regulation Of Cellular Component Movement Central Nervous System Morphogenesis Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Tagcloud ?		1000mg 100mg 300mg aes already arm biliary btcs centers endpoint endpoints favored gemcitabine infused intravenously italy m2 monotherapy multicenter nct00753675 orr pfs placebo plus reporting tolerability v vandetanib worsening