SVIL and P2RX7

Number of citations of the paper that reports this interaction (PMID 11707406)
76

Data Source:
HPRD (in vivo)

		SVIL	P2RX7
Gene Name		supervillin	purinergic receptor P2X, ligand gated ion channel, 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Terminal Bouton Protein Complex Membrane Raft
	Molecular Function	Protein Binding Actin Filament Binding	Magnesium Ion Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity Scaffold Protein Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Cell Volume Homeostasis Membrane Budding Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Neuronal Action Potential Sensory Perception Of Pain Cytolysis Positive Regulation Of Bone Mineralization Cellular Response To Extracellular Stimulus Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway T Cell Proliferation Response To Drug T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Multicellular Organismal Protein Catabolic Process Innate Immune Response Phospholipid Translocation Negative Regulation Of Bone Resorption Positive Regulation Of Cytolysis Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Protein Oligomerization Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Lymphocyte Apoptotic Process Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cation Transmembrane Transport
Pathways			The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS		Normalized brain volume ( 19010793)	Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		37 interactors: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LIMA1 LMNA LMNB2 LUC7L2 MIF4GD MKL2 MPHOSPH9 NME2 NR3C1 ODF2 P2RX7 PAN3 PCNXL3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	9 interactors: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1
Entrez ID		6840	5027
HPRD ID		04992	03977
Ensembl ID		ENSG00000197321	ENSG00000089041
Uniprot IDs		O95425 Q569J5	Q99572
PDB IDs		2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Organelle Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Gene Expression Establishment Of Organelle Localization Apoptotic Process Transcription, DNA-templated Programmed Cell Death Regulation Of Signaling Microtubule-based Process Steroid Hormone Mediated Signaling Pathway Developmental Process Cell Death Death Establishment Of Localization In Cell RNA Biosynthetic Process Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Organelle Organization Transcription From RNA Polymerase II Promoter Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Organelle Localization Heterocycle Metabolic Process Establishment Of Protein Localization Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process
Tagcloud ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?