P2RX7 and KRT34

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P2RX7	KRT34
Description		purinergic receptor P2X 7	keratin 34
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Synapse Presynapse Postsynapse	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding ATP Binding GTP Binding Channel Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	MAPK Cascade Cell Morphogenesis Phagolysosome Assembly T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell Volume Homeostasis Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Protein Secretion Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Response To Zinc Ion Gene Expression Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Programmed Cell Death Glutamate Secretion Positive Regulation Of Glutamate Secretion Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Organophosphate Ester Transport Synaptic Vesicle Exocytosis Protein Processing Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Calcium-mediated Signaling Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process NAD Transport Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phospholipid Translocation Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Regulation Of Transport Positive Regulation Of Cellular Component Organization Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Establishment Of Localization In Cell Mitochondrial Depolarization Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Potassium Ion Transmembrane Transport Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Bleb Assembly	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Keratinization Formation of the cornified envelope
Drugs		Promethazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Interacting Genes		18 interacting genes: ACTB CASK CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 SVIL TM9SF1 TRIM27 ZNF655	261 interacting genes: A1CF ABHD15 ABI2 ADRA2C AGXT AIMP2 ALDH3B1 AMOT ANKRD11 ANKS1A ARMC7 ASMTL ATG9A ATOSB ATPAF2 BATF2 BCAS2 BEX1 BEX2 BEX3 BHLHE23 BOLA3 BRME1 C11orf87 C17orf50 C1orf216 CBX8 CCDC120 CCDC13 CCDC146 CCDC196 CCDC198 CCDC24 CCDC28A-AS1 CCHCR1 CCNC CDC20B CDK18 CERK CFAP206 CFAP53 CFAP90 CHRD CHRNG CLCNKA CLDN19 CLEC18A CTRC CWC25 CYSRT1 CYTH4 DCTN3 DDIT4L DDX6 DHRS1 DMRT3 DOCK2 EFCAB3 EIF4G1 EPDR1 EXOC8 EXOSC5 FAM110A FAM50B FAM83A FAM90A1 FARS2 FBXL9P FBXW5 FNDC11 FOXD4L1 FRS3 GADD45GIP1 GARIN6 GAST GATAD2A GEM GLYCTK GNE GNG10 GNG13 GPS2 GRN GSC2 GSTP1 HAPLN2 HBA1 HBA2 HCK HDAC4 HGS HOXA1 HOXB5 HOXB9 HOXC8 HSPA12B HSPD1 HYAL2 ICAM4 INIP INO80B ISCU ITGB5 ITPKB JOSD1 KANK2 KCTD9 KDELR1 KIDINS220 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT77 KRT78 KRT79 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP12-2 KRTAP13-1 KRTAP19-5 KRTAP19-7 KRTAP26-1 LMO2 LMO4 LRRC41 LYSMD1 LYVE1 MAB21L2 MAD2L2 MAP3K7CL MAPKBP1 MATR3 MBD3L2 METTL17 MIDN MIIP MKRN3 MNS1 MOS MSRB3 MYO15B MYOZ1 MYOZ3 NAB2 NAXD NEK6 NFKBID NMU NOTO NPBWR2 NUP42 P2RX7 PDE9A PDGFRB PGAP6 PGLYRP3 PIN1 PITX1 PITX2 PKN1 PLLP POP5 PPP1R18 PPP1R27 PPP3R2 PRF1 PRPF18 PRPF31 PRR19 PRR35 PSMA1 PSMB1 PTPMT1 R3HDM2 RAB33A RAB3IL1 RASD1 RFC5 RIN1 RIPPLY1 RPS19BP1 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SIRPA SLC15A2 SLC22A5 SLC23A1 SLC25A42 SMARCD1 SMARCE1 SMCP SMG9 SNRPB SPAG8 SPATA46 SPRY3 STMN3 SUOX TACO1 TAPBPL TBC1D22B TCHP TEKT3 TEKT4 TENT5B TEPSIN TFAP2D THAP7 TLE5 TLX3 TMEM174 TMIE TMSB4X TRARG1 TRIM42 TRIM73 TRIML2 TSG101 TTC23 TTC9C TXLNA TXLNB USP2 UTP14C UTP23 VENTX WDR25 WWOX ZDHHC1 ZFHX3 ZFYVE26 ZIC1 ZNF124 ZNF148 ZNF319 ZNF414 ZNF446 ZNF580 ZNF581 ZNF79
Entrez ID		5027	3885
HPRD ID		03977	04137
Ensembl ID		ENSG00000089041	ENSG00000131737
Uniprot IDs		Q99572	O76011
PDB IDs
Enriched GO Terms of Interacting Partners?			Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Keratinization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Supramolecular Fiber Organization Cytoskeleton Organization Axonemal A Tubule Inner Sheath Polymeric Cytoskeletal Fiber Axonemal Microtubule
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