P2RX7 and EFNB3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		P2RX7	EFNB3
Description		purinergic receptor P2X 7	ephrin B3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Synapse Presynapse Postsynapse	Plasma Membrane Membrane Presynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding ATP Binding GTP Binding Channel Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Phagolysosome Assembly T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell Volume Homeostasis Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Protein Secretion Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Response To Zinc Ion Gene Expression Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Programmed Cell Death Glutamate Secretion Positive Regulation Of Glutamate Secretion Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Organophosphate Ester Transport Synaptic Vesicle Exocytosis Protein Processing Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Calcium-mediated Signaling Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process NAD Transport Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phospholipid Translocation Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Regulation Of Transport Positive Regulation Of Cellular Component Organization Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Establishment Of Localization In Cell Mitochondrial Depolarization Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Potassium Ion Transmembrane Transport Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Bleb Assembly	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition Cell Differentiation T Cell Costimulation Symbiont Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Promethazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Alcohol consumption ( 31358974)
Interacting Genes		18 interacting genes: ACTB CASK CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 SVIL TM9SF1 TRIM27 ZNF655	8 interacting genes: AATF ELOC EPHA4 EPHB3 P2RX7 RELN RHBDL2 YWHAZ
Entrez ID		5027	1949
HPRD ID		03977	03804
Ensembl ID		ENSG00000089041	ENSG00000108947
Uniprot IDs		Q99572	Q15768
PDB IDs			4BKF
Enriched GO Terms of Interacting Partners?			Neuron Recognition Regulation Of Synapse Organization Cell Recognition Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Central Nervous System Projection Neuron Axonogenesis Regulation Of Synapse Maturation Positive Regulation Of Dendrite Morphogenesis Neuron Projection Guidance Axon Guidance Central Nervous System Neuron Axonogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Nervous System Development Ephrin Receptor Signaling Pathway Regulation Of Dendrite Morphogenesis DH Domain Binding Lysosome Organization Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cell Adhesion Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cell Projection Organization Neuromuscular Junction Fasciculation Of Motor Neuron Axon Positive Regulation Of Bleb Assembly Synaptic Target Recognition Regulation Of Dendrite Development Regulation Of Neuron Projection Development Regulation Of Nervous System Development Protein Metabolic Process Macromolecule Catabolic Process Neuron Projection Development Dendrite Fasciculation Of Sensory Neuron Axon Cell Projection Organization Phospholipid Transfer To Membrane Positive Regulation Of Gamma-aminobutyric Acid Secretion Lateral Motor Column Neuron Migration Lipoprotein Particle Receptor Binding Positive Regulation Of Cellular Component Organization Protein Tyrosine Kinase Activity Phagolysosome Assembly NAD Transport
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