P2RX7 and ZNF655

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P2RX7	ZNF655
Description		purinergic receptor P2X 7	zinc finger protein 655
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Synapse Presynapse Postsynapse	Nucleus Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding ATP Binding GTP Binding Channel Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Phagolysosome Assembly T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell Volume Homeostasis Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Protein Secretion Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Response To Zinc Ion Gene Expression Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Programmed Cell Death Glutamate Secretion Positive Regulation Of Glutamate Secretion Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Organophosphate Ester Transport Synaptic Vesicle Exocytosis Protein Processing Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Calcium-mediated Signaling Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process NAD Transport Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phospholipid Translocation Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Regulation Of Transport Positive Regulation Of Cellular Component Organization Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Establishment Of Localization In Cell Mitochondrial Depolarization Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Potassium Ion Transmembrane Transport Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Bleb Assembly	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Generic Transcription Pathway
Drugs		Promethazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Serum metabolite levels ( 23093944)
Interacting Genes		18 interacting genes: ACTB CASK CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 SVIL TM9SF1 TRIM27 ZNF655	156 interacting genes: ACSL6 ANKRD11 AP1M1 ASB6 ASMTL ATOSB ATPAF2 BARD1 BORCS6 BYSL C8orf34 C8orf74 CAPN7 CARD9 CBY2 CCDC116 CCDC179 CCDC57 CCDC74A CCHCR1 CCNH CDC37 CDK4 CDR2L CEP57L1 CPNE7 CRACR2A CWF19L2 DBF4B DEUP1 DPF2 DUSP4 EGLN3 EIF4EBP1 EMILIN1 EVL EXOSC5 FADS2 FAM81A FAM81B FAM90A1 FARS2 FBXL9P FHL2 FKBP6 GEM GFAP GSTP1 GUCD1 HAPLN2 HEXIM2 HOMER3 HOOK1 HOXB5 HPCAL1 HSD3B7 HTT HUNK IDI1 IMP3 INTS10 INTS13 IP6K3 ITGB5 JRK KIFC3 KRT40 KRT76 KRT85 KRT86 KRTAP4-12 KRTAP5-9 KRTAP9-8 LCE3C LCE4A LCE5A LGALS14 LMO2 LNX1 MACO1 MAD2L2 MAGEA11 MAGEA2B MBD3 MED21 MEMO1 METTL21A MIS18A MITD1 MPP3 MRFAP1 MRPL28 MTMR9 MTUS2 MXI1 NAA10 NDC80 NECAB2 NGB NOTUM NUDT21 NUDT22 NXT2 OIP5 OSTF1 OTUD4 P2RX7 PBX3 PCSK5 PFKFB1 POLR1C PRR35 RIN3 RINT1 RRM1 RUNX1T1 SH2D4A SIGLEC6 SLC12A4 SMARCD1 SMG9 SPANXN2 SPRED1 SPRY3 SRGAP2B SZT2 TCEANC TEKT4 TEX28 THAP6 TIMM10 TLK1 TNS2 TRAF2 TRAF5 TRAPPC2 TRAPPC2B TRIM37 TRIM41 TRIM72 TRIP13 TSPYL4 TXNDC9 USHBP1 VAV1 VPS26C VPS9D1 XPA YPEL5 ZBTB16 ZC2HC1C ZNF330 ZNF552 ZNF648 ZNF792 ZNF837
Entrez ID		5027	79027
HPRD ID		03977	11673
Ensembl ID		ENSG00000089041	ENSG00000197343
Uniprot IDs		Q99572	Q8N720
PDB IDs			8PK6
Enriched GO Terms of Interacting Partners?			Protein Binding Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition TRAF2-GSTP1 Complex Keratinization Intermediate Filament
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