P2RX7 and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		P2RX7	EFEMP2
Description		purinergic receptor P2X 7	EGF-like fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Synapse Presynapse Postsynapse	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding ATP Binding GTP Binding Channel Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity
	Biological Process	MAPK Cascade Cell Morphogenesis Phagolysosome Assembly T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell Volume Homeostasis Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Protein Secretion Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Response To Zinc Ion Gene Expression Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Programmed Cell Death Glutamate Secretion Positive Regulation Of Glutamate Secretion Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Organophosphate Ester Transport Synaptic Vesicle Exocytosis Protein Processing Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Calcium-mediated Signaling Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process NAD Transport Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phospholipid Translocation Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Regulation Of Transport Positive Regulation Of Cellular Component Organization Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Establishment Of Localization In Cell Mitochondrial Depolarization Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Potassium Ion Transmembrane Transport Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Bleb Assembly	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Artery Development Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Promethazine
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Monocyte count ( 32888494) Retinal detachment or retinal break ( 31816047)
Interacting Genes		18 interacting genes: ACTB CASK CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 SVIL TM9SF1 TRIM27 ZNF655	133 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 DYRK1A FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO FXR1 GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SHANK3 SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837
Entrez ID		5027	30008
HPRD ID		03977	05221
Ensembl ID		ENSG00000089041	ENSG00000172638
Uniprot IDs		Q99572	O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?			Protein Binding Keratinization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Epidermis Development Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of RNA Metabolic Process CD4 Receptor Binding Regulation Of Primary Metabolic Process Tissue Development Regulation Of Nucleobase-containing Compound Metabolic Process TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Nucleus Sequence-specific Double-stranded DNA Binding Intermediate Filament Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Zinc Ion Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?