SVIL and TNFAIP1

Number of citations of the paper that reports this interaction (PMID 20309963)
11

Data Source:
BioGRID (two hybrid)

		SVIL	TNFAIP1
Gene Name		supervillin	tumor necrosis factor, alpha-induced protein 1 (endothelial)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium	Nucleolus Cytoplasm Endosome Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Actin Filament Binding	Ubiquitin-protein Transferase Activity Protein Binding GTP-Rho Binding Protein Domain Specific Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis	DNA Replication Apoptotic Process Immune Response Embryo Development Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Normalized brain volume ( 19010793)
Protein-Protein Interactions		37 interactors: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LIMA1 LMNA LMNB2 LUC7L2 MIF4GD MKL2 MPHOSPH9 NME2 NR3C1 ODF2 P2RX7 PAN3 PCNXL3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	21 interactors: ARMC7 ARNT CAPN7 CARD9 CSNK2B CUL3 EPHA2 EPM2AIP1 EXOSC5 HAT1 KCTD13 KDM1A POLR1C PSMA1 RHOA RHOB RIN3 STK16 SUV39H1 SVIL ZDHHC17
Entrez ID		6840	7126
HPRD ID		04992	01856
Ensembl ID		ENSG00000197321	ENSG00000109079
Uniprot IDs		O95425 Q569J5	Q13829
PDB IDs		2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Organelle Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Gene Expression Establishment Of Organelle Localization Apoptotic Process Transcription, DNA-templated Programmed Cell Death Regulation Of Signaling Microtubule-based Process Steroid Hormone Mediated Signaling Pathway Developmental Process Cell Death Death Establishment Of Localization In Cell RNA Biosynthetic Process Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Organelle Organization Transcription From RNA Polymerase II Promoter Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Organelle Localization Heterocycle Metabolic Process Establishment Of Protein Localization Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process	Regulation Of Signal Transduction Regulation Of Signaling Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokinesis Regulation Of Cytokinesis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Cycle Process Positive Regulation Of Hormone Biosynthetic Process Stress Fiber Assembly Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Division Response To Stress Negative Regulation Of Rho Protein Signal Transduction Regulation Of Cellular Process Regulation Of Hormone Biosynthetic Process Regulation Of Epithelial Cell Migration Cell Morphogenesis Involved In Differentiation Axon Guidance Negative Regulation Of Intracellular Signal Transduction Chromatin Silencing Regulation Of Hormone Metabolic Process Locomotion Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Erythrocyte Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To External Stimulus Cell Cycle Regulation Of Cell Cycle Process Regulation Of Gene Expression, Epigenetic Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Cycle Axonogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Primitive Erythrocyte Differentiation Notochord Cell Development Viral Process Movement Of Cell Or Subcellular Component Axon Development Rho Protein Signal Transduction Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cell Division
Tagcloud ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Difference) ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	adjacent ancts cancerous collectively concerning cytometric distant downregulation experiment immunohistochemical inducible invasion knockdown lentiviral metalloproteinase metastases metastasis microarray mmp mtt os osteosarcoma p65 pcna proliferating sirna transwell upregulation
Tagcloud (Intersection) ?