SVIL and KIF22

Number of citations of the paper that reports this interaction (PubMedID 20309963)
81

Data Source:
BioGRID (two hybrid)

		SVIL	KIF22
Description		supervillin	kinesin family member 22
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GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction	Kinetochore Chromatin Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Nuclear Speck Mitotic Spindle
	Molecular Function	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Nucleotide Binding DNA Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development	Mitotic Cell Cycle DNA Repair Microtubule-based Movement Sister Chromatid Cohesion Mitotic Metaphase Chromosome Alignment Metaphase Chromosome Alignment
Pathways			MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)	Red blood cell traits ( 23222517)
Interacting Genes		36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG	8 interacting genes: ATXN1 GDF9 IMMT PJA1 SIAH1 SVIL UBC WEE2-AS1
Entrez ID		6840	3835
HPRD ID		04992	04445
Ensembl ID		ENSG00000197321	ENSG00000079616
Uniprot IDs		A0A6I8PIX7 O95425 Q569J5	A0A8I5QL17 B7Z9T5 Q14807
PDB IDs		2K6M 2K6N	2EDU 6NJE
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process
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