SVIL and SH3PXD2A

Number of citations of the paper that reports this interaction (PMID 20309963)
11

Data Source:
BioGRID (two hybrid)

		SVIL	SH3PXD2A
Gene Name		supervillin	SH3 and PX domains 2A
Image
Gene Ontology Annotations	Cellular Component	Podosome Nucleus Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium	Podosome Cytoplasm Cell Junction Cell Projection
	Molecular Function	Protein Binding Actin Filament Binding	Protein Binding Phosphatidylinositol Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis	Superoxide Metabolic Process
Pathways
Drugs
Diseases
GWAS		Normalized brain volume ( 19010793)
Protein-Protein Interactions		37 interactors: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LIMA1 LMNA LMNB2 LUC7L2 MIF4GD MKL2 MPHOSPH9 NME2 NR3C1 ODF2 P2RX7 PAN3 PCNXL3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	6 interactors: ADAM15 FASLG KHDRBS1 PAK2 SRC SVIL
Entrez ID		6840	9644
HPRD ID		04992	10228
Ensembl ID		ENSG00000197321	ENSG00000107957
Uniprot IDs		O95425 Q569J5	B3KPL1 F5GZ35 Q5TCZ1
PDB IDs		2K6M 2K6N	2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Organelle Organization Mitotic Cell Cycle Cell Cycle Process Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Cellular Biosynthetic Process Intracellular Receptor Signaling Pathway Mitotic Nuclear Division Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Gene Expression Establishment Of Organelle Localization Apoptotic Process Transcription, DNA-templated Programmed Cell Death Regulation Of Signaling Microtubule-based Process Steroid Hormone Mediated Signaling Pathway Developmental Process Cell Death Death Establishment Of Localization In Cell RNA Biosynthetic Process Metaphase Plate Congression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Organelle Organization Transcription From RNA Polymerase II Promoter Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Organelle Localization Heterocycle Metabolic Process Establishment Of Protein Localization Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process	Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell-substrate Adhesion Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response T Cell Costimulation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Peptidyl-serine Phosphorylation Regulation Of Cell-matrix Adhesion Integrin-mediated Signaling Pathway Regulation Of Proteolysis Cell Development Positive Regulation Of RNA Export From Nucleus Cellular Response To Progesterone Stimulus Cell Morphogenesis Involved In Differentiation Regulation Of Protein Binding Regulation Of Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Endosomal Lumen Acidification Negative Regulation Of Cellular Metabolic Process System Development Immune System Process Regulation Of Protein Metabolic Process Retinal Cell Programmed Cell Death Regulation Of Cell-substrate Adhesion Regulation Of Cell Cycle Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Protein Autophosphorylation Positive Regulation Of Integrin Activation Positive Regulation Of Podosome Assembly Negative Regulation Of Mitochondrial Depolarization Cell-substrate Adhesion Positive Regulation Of Homotypic Cell-cell Adhesion Apoptotic Process
Tagcloud ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	6beta analyzing bands bisphosphate cleft confers crest diverges essentiality exon exons homozygous hypothesize intron invadosome isoform lacked lacks leaving mefs named palate scaffold start tags tks5 tks5beta triplet
Tagcloud (Difference) ?		10p11 a549 abundant actin bipartite bovine bu cdnas comparatively conservation cooh cytoskeleton deleted filaments gland headpiece hela identity message microvilli nh2 originally s3 salivary supervillin sw480 terminus tightly villin	6beta analyzing bands bisphosphate cleft confers crest diverges essentiality exon exons homozygous hypothesize intron invadosome isoform lacked lacks leaving mefs named palate scaffold start tags tks5 tks5beta triplet
Tagcloud (Intersection) ?