P2RX7 and PANX1

Number of citations of the paper that reports this interaction (PMID 17036048)
289

Data Source:
HPRD (in vivo)

		P2RX7	PANX1
Gene Name		purinergic receptor P2X, ligand gated ion channel, 7	pannexin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Terminal Bouton Protein Complex Membrane Raft	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Integral Component Of Membrane Bleb Protein Complex
	Molecular Function	Magnesium Ion Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellular ATP-gated Cation Channel Activity Receptor Binding Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Protein Homodimerization Activity Scaffold Protein Binding	Protease Binding Receptor Binding Calcium Channel Activity Leak Channel Activity Ion Channel Binding Protein Heterodimerization Activity Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Cell Volume Homeostasis Membrane Budding Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Neuronal Action Potential Sensory Perception Of Pain Cytolysis Positive Regulation Of Bone Mineralization Cellular Response To Extracellular Stimulus Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway T Cell Proliferation Response To Drug T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Multicellular Organismal Protein Catabolic Process Innate Immune Response Phospholipid Translocation Negative Regulation Of Bone Resorption Positive Regulation Of Cytolysis Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Protein Oligomerization Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Lymphocyte Apoptotic Process Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cation Transmembrane Transport	Response To Ischemia Cation Transport Calcium Ion Transport Synaptic Transmission Response To ATP Protein Hexamerization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Calcium Ion Transmembrane Transport
Pathways		The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Transmission across Electrical Synapses Electric Transmission Across Gap Junctions Innate Immune System
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Protein-Protein Interactions		9 interactors: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1	2 interactors: GNAS P2RX7
Entrez ID		5027	24145
HPRD ID		03977	10526
Ensembl ID		ENSG00000089041	ENSG00000110218
Uniprot IDs		Q99572	Q96RD7
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Ossification Tissue Homeostasis Regulation Of Ossification Post-embryonic Body Morphogenesis Multicellular Organismal Homeostasis Skeletal System Morphogenesis Phospholipid Transfer To Membrane NAD Transport Homotypic Cell-cell Adhesion Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Secretion Positive Regulation Of Cytolysis Multicellular Organismal Protein Catabolic Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Glutamate Secretion Multicellular Organismal Protein Metabolic Process Positive Regulation Of Interleukin-1 Alpha Production Secretion By Cell Response To Drug Single Organismal Cell-cell Adhesion Positive Regulation Of Gamma-aminobutyric Acid Secretion Skeletal System Development Regulation Of Protein Transport Secretion Regulation Of Secretion Regulation Of Killing Of Cells Of Other Organism Bleb Assembly Positive Regulation Of Mitochondrial Depolarization Regulation Of Establishment Of Protein Localization Cell Activation Positive Regulation Of Amino Acid Transport Pore Complex Assembly Negative Regulation Of Bone Resorption Regulation Of Glutamate Secretion Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Response To Parathyroid Hormone Phagolysosome Assembly Regulation Of Protein Localization Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Bone Remodeling Positive Regulation Of Prostaglandin Secretion Sensory Perception Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Response To Lipid Adrenergic Receptor Signaling Pathway Chemical Homeostasis Negative Regulation Of Tissue Remodeling Response To Organic Cyclic Compound
Tagcloud ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	afferent apical arteries arterioles atp channels collecting conduit connexin descending ducts efferent electrolyte freshly limbs lumen mechanosensitive multifaceted participate purinergic reabsorption released stimulates thin tubular tubules ubiquitously vasculature
Tagcloud (Difference) ?		adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 evl fbxw7 galns gnas iranian lgr mmp2 msi msp mss parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22	afferent apical arteries arterioles atp channels collecting conduit connexin descending ducts efferent electrolyte freshly limbs lumen mechanosensitive multifaceted participate purinergic reabsorption released stimulates thin tubular tubules ubiquitously vasculature
Tagcloud (Intersection) ?