SUV39H1 and CEP70

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SUV39H1	CEP70
Description		SUV39H1 histone lysine methyltransferase	centrosomal protein 70
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence	Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Femur bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072)
Interacting Genes		137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9	245 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATOSB ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DRC4 DVL3 DYRK1A EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM90A1 GADD45GIP1 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEA2 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF250 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		6839	80321
HPRD ID		02221	16779
Ensembl ID		ENSG00000101945	ENSG00000114107
Uniprot IDs		O43463	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs		3MTS
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleolus RNA Processing Nuclear Speck Spliceosomal Complex Nucleoplasm RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone Acetyltransferase Complex Chromatin Organization Nuclear Androgen Receptor Binding Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Transcription Elongation By RNA Polymerase II RRNA Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Binding DNA-templated Transcription Elongation RNA Metabolic Process Histone H3-K14 Acetyltransferase Complex MRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process Nucleic Acid Metabolic Process
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