SUV39H1 and FYN

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		SUV39H1	FYN
Description		SUV39H1 histone lysine methyltransferase	FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex Chromosome Nucleolus Plasma Membrane Membrane Cytoplasmic Vesicle RDNA Heterochromatin ENoSc Complex	Nucleus Cytoplasm Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Membrane Dendrite Perikaryon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Cell Periphery Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity Histone H3K9 Trimethyltransferase Activity	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Tubulin Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Formation Blastocyst Hatching Regulation Of DNA Repair Chromatin Organization RRNA Processing DNA Damage Response Circadian Rhythm Determination Of Adult Lifespan Cell Differentiation Regulation Of Bone Mineralization Heterochromatin Formation Methylation Regulation Of Multicellular Organism Growth Cellular Response To Glucose Starvation Epigenetic Programming In The Zygotic Pronuclei Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By Glucose Rhythmic Process Cellular Response To Hypoxia Energy Homeostasis Regulation Of Cellular Senescence	Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heart Process Calcium Ion Transport Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Axon Guidance Learning Feeding Behavior Regulation Of Cell Shape Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Protein Ubiquitination Peptidyl-tyrosine Phosphorylation Layer Formation In Cerebral Cortex Natural Killer Cell Activation Cell Differentiation Protein Catabolic Process Forebrain Development Neuron Projection Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Cocaine Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Neuron Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression	GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Dasatinib Triglyme Fostamatinib Zotiraciclib
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		137 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRT31 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9	199 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B GRSF1 HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PRRG4 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		6839	2534
HPRD ID		02221	00655
Ensembl ID		ENSG00000101945	ENSG00000010810
Uniprot IDs		O43463	P06241
PDB IDs		3MTS	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ 7A2J 7A2K 7A2L 7A2M 7A2N 7A2O 7A2P 7A2Q 7A2R 7A2S 7A2T 7A2U 7A2V 7A2W 7A2X 7A2Y 7A2Z 7UD6 8KDX
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Chromatin Organization Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Primary Metabolic Process DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Binding Regulation Of Metabolic Process Heterochromatin Formation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding Chromatin Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process ESC/E(Z) Complex Chromatin Transcription Corepressor Binding Negative Regulation Of Metabolic Process Histone Deacetylase Complex Transcription Corepressor Activity Promoter-specific Chromatin Binding Negative Regulation Of Gene Expression DNA (cytosine-5-)-methyltransferase Activity Protein Lysine Delactylase Activity Chromatin DNA Binding Histone Deacetylase Activity, Hydrolytic Mechanism DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Chromosome, Telomeric Region Negative Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Lipid Kinase Activity	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Cell Adhesion Leukocyte Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Lymphocyte Activation Positive Regulation Of Cell Adhesion Membrane Raft Regulation Of Cell Activation T Cell Receptor Signaling Pathway Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Immune Response Regulation Of Cell-cell Adhesion Regulation Of Programmed Cell Death Intracellular Signaling Cassette Fc Receptor Signaling Pathway Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response Cell Adhesion Protein Kinase Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?