SUV39H1 and MALT1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		SUV39H1	MALT1
Gene Name		suppressor of variegation 3-9 homolog 1 (Drosophila)	MALT1 paracaspase
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane CBM Complex Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Peptidase Activity Kinase Activator Activity Protein Self-association
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Organization Transcription, DNA-templated RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Gene Expression Viral Process Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia	B-1 B Cell Differentiation Response To Molecule Of Bacterial Origin Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Protein Oligomerization
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) TCR signaling FCERI mediated NF-kB activation Downstream TCR signaling Activation of NF-kappaB in B cells Fc epsilon receptor (FCERI) signaling Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		123 interactors: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C17orf82 C4orf17 C8orf74 CBX1 CBX4 CBX5 CCDC151 CCDC37 CDC23 CDCA4 CDCA7L CEP70 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GPATCH2L GTF2H2C_2 GTPBP2 H3F3C HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HIST1H3A HIST2H3A HIST3H3 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 LDHAL6B LENG8 LHX8 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 OPA3 PHF19 PML PNKP PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEX35 THRA TMEM11 TNFAIP1 U2AF1 WDFY3 WIZ ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF436 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZSCAN9	12 interactors: BCL10 CARM1 IKBKG KDM1A PRMT6 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBE2N UBE2V2
Entrez ID		6839	10892
HPRD ID		02221	06892
Ensembl ID		ENSG00000101945	ENSG00000172175
Uniprot IDs		B4DST0 O43463	A8K5S1 Q9UDY8
PDB IDs		3MTS	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1R
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Organelle Organization Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone Modification Histone H4 Deacetylation Cellular Process Regulation Of Cell Cycle Metabolic Process	Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Protein K63-linked Ubiquitination NIK/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Innate Immune Response Response To Stress Regulation Of Nitrogen Compound Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Cell Death Activation Of NF-kappaB-inducing Kinase Activity T Cell Receptor Signaling Pathway Histone H3-R2 Methylation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of NIK/NF-kappaB Signaling Regulation Of Cellular Protein Metabolic Process Histone Modification Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Metabolic Process Innate Immune Response Protein Polyubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Intracellular Receptor Signaling Pathway
Tagcloud ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified	api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious
Tagcloud (Difference) ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified	api2 bcl2 cd10 cd23 cd5 demonstration destroying diagnose discrete excludes follicular glandular infiltrate invading lamina lymphatic lymphocytic lymphoepithelial lymphoma lymphomas mantle marginal mucosae propria q21 rearrangement stomach suspicious
Tagcloud (Intersection) ?