SUV39H1 and RRP8

Number of citations of the paper that reports this interaction (PMID 18485871)
68

Data Source:
HPRD (in vivo)

		SUV39H1	RRP8
Gene Name		suppressor of variegation 3-9 homolog 1 (Drosophila)	ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin	Nucleus Nucleoplasm Chromatin Silencing Complex Nucleolus Cytoplasm Plasma Membrane RDNA Heterochromatin
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding	Protein Binding S-adenosylmethionine-dependent Methyltransferase Activity Methylated Histone Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Chromatin Organization Transcription, DNA-templated RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Gene Expression Viral Process Cell Differentiation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Circadian Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia	Chromatin Silencing At RDNA Transcription, DNA-templated RRNA Processing Gene Expression Chromatin Modification Methylation Regulation Of Gene Expression, Epigenetic Cellular Response To Glucose Starvation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription By Glucose Positive Regulation Of Cell Cycle Arrest Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression	Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression SIRT1 negatively regulates rRNA Expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		123 interactors: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C17orf82 C4orf17 C8orf74 CBX1 CBX4 CBX5 CCDC151 CCDC37 CDC23 CDCA4 CDCA7L CEP70 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DNMT1 DNMT3A DNMT3B ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GPATCH2L GTF2H2C_2 GTPBP2 H3F3C HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HIST1H3A HIST2H3A HIST3H3 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 LDHAL6B LENG8 LHX8 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 OPA3 PHF19 PML PNKP PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEX35 THRA TMEM11 TNFAIP1 U2AF1 WDFY3 WIZ ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF436 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZSCAN9	2 interactors: SIRT1 SUV39H1
Entrez ID		6839	23378
HPRD ID		02221	13800
Ensembl ID		ENSG00000101945
Uniprot IDs		B4DST0 O43463	O43159
PDB IDs		3MTS	2ZFU
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Modification Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromosome Organization Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Organelle Organization Chromatin Silencing Gene Silencing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone Modification Histone H4 Deacetylation Cellular Process Regulation Of Cell Cycle Metabolic Process	Chromatin Silencing At RDNA Chromatin Silencing Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Gene Silencing Cellular Response To Oxygen Levels RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Regulation Of Gene Expression, Epigenetic Establishment Of Chromatin Silencing Negative Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Cellular Response To Testosterone Stimulus Peptidyl-lysine Modification Response To Hypoxia Behavioral Response To Starvation Rhythmic Process Ribonucleoprotein Complex Biogenesis Maintenance Of Chromatin Silencing Negative Regulation Of Helicase Activity Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Chromatin Silencing Histone Modification Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Cellular Senescence NcRNA Metabolic Process Pyrimidine Dimer Repair By Nucleotide-excision Repair Positive Regulation Of Macrophage Apoptotic Process Histone H3-K9 Dimethylation Viral Process Peptidyl-lysine Deacetylation Methylation-dependent Chromatin Silencing Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of MHC Class II Biosynthetic Process Chromatin Modification Positive Regulation Of Cell Aging Triglyceride Mobilization Cellular Triglyceride Homeostasis Negative Regulation Of Cellular Senescence Positive Regulation Of Myeloid Cell Apoptotic Process Histone H3-K9 Trimethylation Chromatin Organization Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ovulation From Ovarian Follicle Peptidyl-lysine Dimethylation Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Bile Acid Biosynthetic Process
Tagcloud ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Difference) ?		adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly setdb1 t98g verified
Tagcloud (Intersection) ?