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SUPT5H and H2AX
Number of citations of the paper that reports this interaction (PubMedID
28242625
)
72
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(two hybrid)
SUPT5H
H2AX
Description
SPT5 homolog, DSIF elongation factor subunit
H2A.X variant histone
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DSIF Complex
Chromosome, Telomeric Region
Chromatin
Nucleosome
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Centrosome
Nuclear Speck
Site Of Double-strand Break
Extracellular Exosome
Site Of DNA Damage
Molecular Function
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Heterodimerization Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Structural Constituent Of Chromatin
Histone Binding
Protein Heterodimerization Activity
Chromatin-protein Adaptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription Elongation
Regulation Of Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Positive Regulation Of Macroautophagy
Regulation Of DNA-templated Transcription Elongation
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of Transcription Elongation By RNA Polymerase II
Regulation Of Transcription Elongation By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
DNA Recombination
Nucleosome Assembly
DNA Damage Response
Spermatogenesis
Response To Ionizing Radiation
Heterochromatin Formation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Protein K63-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
RNA Polymerase II Transcription Elongation
RNA Pol II CTD phosphorylation and interaction with CE
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
51 interacting genes:
C9orf78
CCNH
CCNT2
CDK7
CDK9
CEP55
CPSF7
CSNK2A1
DBN1
DCAF6
DSCAM
EXOSC7
FHL3
GOLGA2
GTF3C1
H2AX
HSPB1
HTATSF1
IK
IKBKG
LMAN2
MAD1L1
MAML3
MNAT1
PCBD1
PGK1
PHYHIP
PIN1
PNO1
POLR2A
PPIA
PPP2R2D
PRMT1
PRMT5
RPL9
SAP30BP
SIK1
SNRNP48
SNX4
SSBP3
SUMO2
SUPT4H1
TERF1
TEX11
TLE5
XRCC5
YBX2
ZBTB3
ZFYVE9
ZNF496
ZNF512B
47 interacting genes:
A2M
ACTB
ALG9
ATM
ATR
BAZ1B
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
CTBP1
DDX21
EYA1
GRB2
HDAC6
HUWE1
KAT5
MAPK8
MASP1
MDC1
MRE11
MUC1
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PRKDC
PTEN
PTPA
QARS1
RNF8
RPS6KA3
SMARCA4
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TP53BP1
TRAF6
TSSK6
WRN
Entrez ID
6829
3014
HPRD ID
03655
03465
Ensembl ID
ENSG00000196235
ENSG00000188486
Uniprot IDs
O00267
P16104
PDB IDs
2DO3
2E6Z
2E70
3H7H
4L1U
5OHO
5OHQ
5OIK
5U98
6EQY
6ER0
6GMH
6GML
6TED
7OKX
7OKY
7OL0
7PKS
7UNC
7UND
7YCX
8A3Y
8P4C
8P4D
8P4E
8P4F
8RBX
8UHA
8UHD
8UHG
8UI0
8UIS
8W8E
8W8F
9EGX
9EGY
9EGZ
9EH0
9EH2
9J0N
9J0O
9J0P
1YDP
2AZM
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
6K1I
6K1J
6K1K
6ZWK
7YQK
Enriched GO Terms of Interacting Partners
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Nucleus
Nucleic Acid Metabolic Process
Transcription Factor TFIIK Complex
CAK-ERCC2 Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Cycle
Regulation Of RNA Metabolic Process
DNA-templated Transcription Initiation
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Transcription Factor TFIIH Core Complex
Transcription Factor TFIIH Holo Complex
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Gene Expression
Transcription Elongation By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
Regulation Of Mitotic Cell Cycle
Protein Localization To Chromosome
Regulation Of Macromolecule Metabolic Process
DNA-templated Transcription Elongation
Protein Peptidyl-prolyl Isomerization
Chromosome
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Chromosome Segregation
DNA Metabolic Process
Recombinational Repair
Protein Localization To Site Of Double-strand Break
Protein Binding
DNA Recombination
Transcription Pausing By RNA Polymerase II
Postsynaptic Cytosol
Histone H4R3 Methyltransferase Activity
Peptidyl-arginine Methylation
DNA Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Anoikis
Regulation Of Transcription Elongation By RNA Polymerase II
Transcription Elongation-coupled Chromatin Remodeling
Macromolecule Biosynthetic Process
Regulation Of Cellular Response To Stress
Regulation Of DNA Repair
DNA Damage Response
Signal Transduction In Response To DNA Damage
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA Metabolic Process
DNA Repair
Double-strand Break Repair
Protein Localization To Site Of Double-strand Break
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Nucleoplasm
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Metabolic Process
Cellular Response To Stress
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA Repair
Regulation Of Cell Cycle Process
Protein Localization To Chromosome
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Chromosome, Telomeric Region
Regulation Of Primary Metabolic Process
Intracellular Signal Transduction
Double-strand Break Repair Via Nonhomologous End Joining
Regulation Of DNA Recombination
Nucleic Acid Metabolic Process
Positive Regulation Of Double-strand Break Repair
DNA Damage Checkpoint Signaling
Telomere Maintenance
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle
Chromosome
Positive Regulation Of DNA Recombination
Positive Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Response To Stress
Telomere Organization
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Phase Transition
Mitotic DNA Damage Checkpoint Signaling
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