SUPT5H and CEP55

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		SUPT5H	CEP55
Description		SPT5 homolog, DSIF elongation factor subunit	centrosomal protein 55
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) White blood cell count ( 32888494)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B	94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		6829	55165
HPRD ID		03655	12569
Ensembl ID		ENSG00000196235	ENSG00000138180
Uniprot IDs		O00267	Q53EZ4
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P	3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly
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