SUPT5H and SUPT4H1

Number of citations of the paper that reports this interaction (PubMedID 10454543)
45

Data Source:
HPRD (in vitro)

		SUPT5H	SUPT4H1
Description		SPT5 homolog, DSIF elongation factor subunit	SPT4 homolog, DSIF elongation factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) White blood cell count ( 32888494)	Eosinophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887) Refractive error ( 32231278)
Interacting Genes		51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B	12 interacting genes: ANXA5 APP EWSR1 HTATSF1 LRIF1 LRRK2 MFHAS1 NSG2 PDLIM1 SMARCA2 SUPT5H XRCC5
Entrez ID		6829	6827
HPRD ID		03655	16026
Ensembl ID		ENSG00000196235	ENSG00000213246
Uniprot IDs		O00267	P63272
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P	3H7H 5OIK 6GMH 6GML 6TED 7OKY 7UND 7YCX 8A3Y 8P4C 8P4D 8P4F 8UHA 8UHD 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process	Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Positive Regulation Of Defense Response ATP-dependent Activity, Acting On DNA Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Immune System Process Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Modulation Of Excitatory Postsynaptic Potential Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Activation Epigenetic Regulation Of Gene Expression Endothelial Microparticle Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Defense Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Chromatin Organization Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Negative Regulation Of Macromolecule Biosynthetic Process Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Calcium-mediated Signaling Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DSIF Complex Small-subunit Processome Assembly DNA End Binding
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